Cannabinoid-Monoterpene Topical Composition for Rapid Joint Pain Relief

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Solution Overview

Problem

Existing pharmaceutical compositions that rely solely on cannabinoids provide only partial relief for neuropathic pain, particularly muscle and joint pain, and may have adverse side effects.

Innovation Solution

A topical pharmaceutical composition comprising monoterpenes, cannabinoids, ashwagandha extracts, and dimethyl sulfoxide (DMSO), formulated into a cream, gel, or lotion base, which includes specific ratios and preparation methods to enhance pain relief efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional cannabinoid-based treatments are used for neuropathic pain, then some pain relief is achieved, but adverse side effects occur and relief is only partial

Engineering Contradiction:
Improvepain relief efficacyVSAvoidadverse side effects
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines multiple cannabinoids (CBD, THC, CBC, CBG) with terpenes (limonene, pinene, myrcene, caryophyllene) and ashwagandha extract in a synergistic formulation. This combination approach aims to enhance pain relief efficacy while reducing adverse side effects through the entourage effect, where multiple compounds work together to produce greater therapeutic benefit than individual cannabinoids alone.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite topical composition integrating multiple pharmaceutical ingredients (cannabinoids, terpenes, ashwagandha) with specific ratios and formulations. This composite approach allows optimization of therapeutic effects while managing side effects through balanced composition, distinguishing it from single-component cannabinoid treatments.

Inventive Principle:
Principle #40Composite materials

2Reliability

If cannabinoid-based treatments are used for muscle and joint pain, then some analgesic effect is achieved, but the relief is not rapid or sufficient

Engineering Contradiction:
Improveanalgesic effectVSAvoidonset speed of pain relief
Core Design Contradiction:
ReliabilityVSSpeed

Solution Approach 1:

The patent modifies key parameters of cannabinoid delivery by formulating a topical composition with specific concentrations (CBD 5-20%, THC 5-20%, terpenes 5-20%, ashwagandha 1-5%) and optimizing the vehicle system. This parameter optimization enables rapid absorption and onset of action while maintaining sufficient analgesic effect for muscle and joint pain.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The formulation uses terpenes and ashwagandha extract as intermediary components that enhance the penetration and absorption of cannabinoids into the target tissue. These intermediaries facilitate faster delivery and more rapid onset of analgesic effect compared to cannabinoid-only formulations.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Ease of manufacture

If purified cannabinoids are used to achieve high purity, then manufacturing simplicity is improved, but the therapeutic efficacy is reduced due to loss of synergistic compounds

Engineering Contradiction:
Improvemanufacturing simplicityVSAvoidtherapeutic efficacy
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The patent extracts and isolates specific cannabinoids (CBD, THC, CBC, CBG) and terpenes (limonene, pinene, myrcene, caryophyllene) from cannabis plant material using controlled extraction methods. This selective extraction approach maintains the synergistic relationship between compounds while ensuring manufacturing feasibility and reproducibility of the formulation.

Inventive Principle:
Principle #2Taking out (Extraction)

Solution Approach 2:

The formulation specifies precise parameter ranges for cannabinoid content (CBD 5-20%, THC 5-20%), terpene content (5-20%), and ashwagandha extract (1-5%). These parameter specifications enable standardized manufacturing while preserving the synergistic therapeutic efficacy through controlled composition rather than purified single compounds.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition rapidly and effectively relieves muscle and joint pain without the risks associated with traditional cannabinoid-based treatments, demonstrating superior analgesic effects compared to CBD or CBD+THC creams.

Implementation Method 1

The composition rapidly and effectively relieves muscle and joint pain without the risks associated with traditional cannabinoid-based treatments, demonstrating superior analgesic effects compared to CBD or CBD+THC creams.

Methodology Applied
Scientific EffectSynergistic interaction:

Data Source

PatentUS12357587B2Cannabinoid monoterpene based pharmaceutical topical composition for musculoskeletal pain
Publication Date: 2025.07.15 MOUNTAIN VALLEY MD INC

AI summary

A topical pain relief composition has a base with a mixture of various components such as, but not limited to, a base, d-limonene, cannabinoids or a derivative thereof, ashwagandha extracts and dimethyl sulfoxide (DMSO).