Cannabinoid Pico-Emulsion Formulation for Stable Injectable Delivery
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing methods for cannabinoid delivery, such as smoking, vaping, and edibles, face limitations including respiratory issues, unpredictable potency, and reduced bioavailability due to first-pass metabolism, while injectable formulations offer precision but struggle to achieve stable emulsions in the picometer range, which could enhance bioavailability and provide antibiotic properties.
Innovation Solution
A process involving high-purity cannabinoid isolates and a specific surfactant with HLB 15, such as polysorbate 80, is used to create a stable cannabinoid pico-emulsion with micelles ranging from 4900 to 850 picometers, ensuring stability through adequate surfactant saturation and purification, and sonication to achieve the desired droplet size.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If traditional routes like smoking or edibles are used to deliver cannabis-derived compounds, then the administration is simple and accessible, but the bioavailability is reduced and potency is unpredictable
Solution Approach 1:
The patent changes the physical and chemical parameters of cannabinoid delivery by creating a pico-emulsion formulation with droplet sizes of 4900-850 picometers, using 99% pure cannabinoid isolates instead of full-spectrum extracts, and employing polysorbate 80 surfactant with specific HLB of 15. These parameter changes enable direct intravenous administration with predictable pharmacokinetics and high bioavailability, resolving the contradiction between administration simplicity and reliability.
2Reliability
If injectable formulations are created to improve bioavailability, then the onset of action is immediate and dosing is precise, but achieving stable emulsions in the picometer range is difficult due to impurities and instability
Solution Approach 1:
The patent extracts and removes impurities from the cannabinoid material by using 99% pure cannabinoid isolates rather than full-spectrum extracts. This extraction of unwanted components eliminates the impurities that would otherwise interfere with emulsion stability and picometer-scale droplet formation, enabling both high bioavailability and formulation stability.
Solution Approach 2:
The patent introduces polysorbate 80 surfactant as an intermediary substance with HLB of 15 to stabilize the pico-emulsion. This surfactant acts as a mediator between the hydrophobic cannabinoid isolates and the aqueous carrier, enabling the formation and stabilization of emulsion droplets in the 4900-850 picometer range that would otherwise be unstable and prone to aggregation.
3Adaptability or versatility
If full-spectrum cannabinoid extracts are used, then the product contains a broader range of compounds, but impurities interfere with emulsion stability and droplet size control
Solution Approach 1:
The patent extracts only the specific cannabinoid compounds of interest through isolation processes that achieve 99% purity, removing terpenes, flavonoids, and other compounds present in full-spectrum extracts. This selective extraction eliminates impurities that would interfere with emulsion stability and droplet size control, while still providing the desired therapeutic cannabinoid effects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The pico-emulsion achieves significantly enhanced bioavailability and exhibits potent antibiotic properties against gram-negative bacteria, overcoming resistance and providing rapid therapeutic effects.
Implementation Method 1
polysorbate 80 as a surfactant with a hydrophilic-lipophilic balance of 15
Implementation Method 2
creating a sterile and injectable cannabinoid pico-emulsion
Implementation Method 3
The mixture is then subjected to ultrasonic energy
Data Source
AI summary
A novel process of creating a cannabinoid pico-emulsion resulting in a sterile and injectable cannabinoid emulsion with increased bioavailability and antibiotic characteristics, and the resulting novel cannabinoid pico-emulsion, for the purpose of treating a wide variety of medical condition in both human and animals.