Polycannabinoid Polymer Matrices for Bioavailability and Thermal Stability

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Cannabinoids exhibit low bioavailability and poor thermal stability due to their lipophilic nature and hydrophobicity, leading to challenges in effective dosing and delivery, particularly in aqueous environments and during prolonged storage.

Innovation Solution

Development of polycannabinoid polymers comprising cannabinoid units linked by hydrocarbon chains, which are incorporated into various polymer types such as polyesters, polyurethanes, and polyethers, enhancing bioavailability and thermal stability through polymerization.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If cannabinoids are administered in conventional forms, then they can be easily administered, but they exhibit low bioavailability due to poor dissolution in aqueous environment

Engineering Contradiction:

Improveease of administrationVSAvoidbioavailability

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent combines cannabinoids with biodegradable polymer matrices to create composite delivery systems. These composites enable the hydrophobic cannabinoids to be delivered effectively through aqueous environments while maintaining controlled release profiles and improving bioavailability through sustained delivery mechanisms.

Inventive Principle:

Principle #40Composite materials

2Duration of action of stationary object

If cannabinoids are stored for prolonged periods, then they can be used for sustained treatment, but they degrade due to low thermal stability

Engineering Contradiction:

Improvestorage durationVSAvoidthermal stability

Core Design Contradiction:

Duration of action of stationary objectVSStability of the object's composition

Solution Approach 1:

The patent employs protective polymer matrices that shield cannabinoids from thermal degradation before administration. The biodegradable polymers provide a stable environment during storage, protecting the thermally sensitive cannabinoid molecules from degradation until the point of use.

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

Solution Approach 2:

The patent alters the physical and chemical parameters of cannabinoid delivery by incorporating them into polymer systems with specific degradation rates. This allows the formulation to maintain stability during storage while enabling controlled release under physiological conditions, effectively decoupling storage stability from release kinetics.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If cannabinoids are delivered in sustained release systems, then bioavailability is improved, but the formulation complexity increases

Engineering Contradiction:

ImprovebioavailabilityVSAvoidformulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies different polymer properties and degradation rates to different regions or aspects of the delivery system. By tailoring the local characteristics of the polymer matrix (such as crosslinking density, hydrophilicity, and degradation rate), the formulation achieves improved bioavailability through controlled release without requiring overly complex overall structures.

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The polycannabinoid polymers improve the bioavailability and thermal stability of cannabinoids, enabling sustained and effective delivery systems for medical treatments, including topical applications like stents, bandages, and transdermal patches.

Implementation Method 1

Methodology Applied

Scientific EffectPolymerization:

Data Source

PatentUS20260069617A1Polycannabinoids, compounds, compositions and methods of use

Publication Date: 2026.03.12 UNIV OF CONNECTICUT

AI summary

Polymers comprising a plurality of cannabinoids, methods of preparation thereof, and methods of use to treat a number of disease conditions are reported. Also provided are polymer coatings, films, fibers, and non-woven fabrics for a variety of topical applications including stents, bandages, sutures, and transdermal patches.