Cannabinoid Solubilization via Water-Soluble Carriers
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Solution Overview
Problem
Cannabinoids are lipid-soluble and hydrophilic, making them challenging to deliver orally due to insolubility in water, leading to quick recrystallization and impaired bioavailability when attempting to solubilize them for absorption.
Innovation Solution
A composition comprising cannabinoids in a solubilized form combined with a water-soluble carrier material, such as sugar alcohols or cellulose derivatives, to enhance solubility and stability, allowing for controlled release in an aqueous environment like the oral cavity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cannabinoids are solubilized in water for oral delivery, then bioavailability is improved, but recrystallization occurs quickly reducing stability
Solution Approach 1:
The patent uses water-soluble carrier materials (such as hydrogels, cyclodextrins, or surfactants) as intermediary substances to solubilize cannabinoids in aqueous environments. These carriers form inclusion complexes or micelles that keep cannabinoids dissolved without immediate recrystallization, thereby maintaining both bioavailability and stability during oral delivery.
Solution Approach 2:
The invention creates composite formulations combining cannabinoids with water-soluble carrier materials. This composite approach allows the hydrophobic cannabinoids to be delivered in an aqueous environment through the carrier matrix, preventing phase separation and recrystallization while maintaining solubility and bioavailability.
2Ease of operation
If cannabinoids are delivered orally, then ease of administration is improved, but solubility in water remains poor
Solution Approach 1:
Water-soluble carrier materials serve as mediators that enable oral administration of lipophilic cannabinoids. These carriers form solubilizing complexes that allow cannabinoids to be delivered in water-based formulations, making oral administration feasible while maintaining adequate solubility levels.
Solution Approach 2:
The patent modifies the physical-chemical parameters of cannabinoid delivery by changing from pure lipid-based formulations to water-based formulations with solubility-enhancing carriers. This parameter change enables better mixing with aqueous digestive fluids and improved absorption while maintaining solubility through the carrier system.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively solubilizes and stabilizes cannabinoids, enhancing their bioavailability by facilitating absorption through the mucosa and into the bloodstream, with controlled release profiles to optimize therapeutic effects.
Implementation Method 1
A composition comprising cannabinoids in a solubilized form combined with a water-soluble carrier material, such as sugar alcohols or cellulose derivatives, to enhance solubility and stability
Implementation Method 2
The composition effectively solubilizes and stabilizes cannabinoids, enhancing their bioavailability by facilitating absorption through the mucosa and into the bloodstream
Data Source
AI summary
The present invention relates to compositions comprising a constituent, derivative or extract of cannabis in solution or in a solubilised form. The invention also relates to products including such compositions and methods of manufacturing them.