Cannabinoid Nanoparticle Carrier Composition Using Sonication
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing cannabinoid emulsion technologies are complex and do not produce highly stable, uniformly dispersed suspensions necessary for consistent dosing and therapeutic efficacy, lacking regulatory compliance and safety.
Innovation Solution
A method involving sonication and ultrasonic processing of lipid-based cannabinoid compositions with non-ionic surfactants to create a highly stable nanoemulsion with tailored zeta potential, ensuring uniform particle dispersion and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If conventional cannabinoid emulsion methods are used, then the manufacturing process is simple, but the emulsion stability and uniform dispersion are poor
Solution Approach 1:
The patent changes physical parameters by applying sonication energy to reduce particle size to nanoscale and modifies chemical parameters by adjusting pH to specific ranges (5-10) and controlling water content (1-20%), thereby achieving stable nanoemulsion formation without complex equipment
Solution Approach 2:
The patent replaces complex mechanical mixing systems with acoustic field-based sonication, using ultrasonic waves to achieve uniform dispersion and stable emulsion formation, simplifying the overall manufacturing process while improving emulsion stability
2Manufacturing precision
If conventional cannabinoid emulsion methods are used, then the process is straightforward, but consistent dosing and therapeutic efficacy cannot be ensured
Solution Approach 1:
The patent replaces conventional mechanical mixing with sonication technology, using acoustic energy to create uniform nanoparticle dispersion that ensures consistent dosing while maintaining manufacturing simplicity through a straightforward one-step process
Solution Approach 2:
The patent controls critical parameters including particle size (nanoscale), pH (5-10), and water content (1-20%) to achieve uniform dispersion and consistent dosing, with these parameter controls being achievable through simple sonication processing rather than complex manufacturing
3Stability of the object's composition
If cannabinoid oils are mixed with surfactants and processed, then nanoemulsion stability is improved, but the process time and energy consumption increase
Solution Approach 1:
The patent uses sonication, which delivers energy rapidly through acoustic waves, to achieve nanoemulsion formation much faster than conventional mechanical mixing, reducing processing time while maintaining high stability through the efficient creation of uniform nanoparticle dispersion
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Produces a cannabinoid nanoemulsion with optimal zeta potential, achieving stable uniform distribution, improved solubility, and consistent dosing for therapeutic applications.
Implementation Method 1
processing the mixture made in step (a) using sonication for a predetermined time at a predetermined amplification until completely processed and substantially all of the cannabinoid oils are reduced to nanoparticle size
Implementation Method 2
sonicating the mixture made in step (d) using an ultrasonic liquid processor operated at a predetermined amplitude for a predetermined time
Implementation Method 3
mixing non-ionic surfactants with cannabinoid oils and lipids in a mixing vessel
Implementation Method 4
create a highly stable cannabinoid nanoemulsion
Implementation Method 5
having high zeta potential, and thus comprise highly stable nanoemulsions in which the colloids are highly resistant to caking
Data Source
AI summary
A highly stable cannabinoid nanoparticle carrier composition for administration to a human made by incorporating non-ionic surfactants with cannabinoid oils and lipids, sonicating for a predetermined period of time at a predetermined amplification with an ultrasonic liquid processor until completely integrated; combining the mixture with a carrier fluid that includes ascorbic acid and distilled water; and further sonicating the mixture using an ultrasonic liquid processor at predetermined amplitude for a predetermined period of time at a controlled temperature, and thereby to create a CBD nanoemulsion. The composition is tailored using non-ionic surfactants to adsorb to the surface of the cannabinoid oil particles to advantageously affect electrokinetics and surface forces at the interface of the bioactive cannabinoid particles and the suspending liquid are controlled by tailoring the suspending liquid to maximize the zeta potential.