Cannabinoid Tablet Compression Without Excipients
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Solution Overview
Problem
Existing dosage forms of cannabinoids, particularly cannabidiol, face challenges in achieving accurate and precise dosing without the use of flow agents or binder agents, which can affect the purity and particle size distribution of the cannabinoid.
Innovation Solution
The development of a dosage form comprising cannabinoids, such as cannabidiol, pressed into tablets without the need for flow agents or binder agents, by selecting a specific purity and particle size distribution range that allows for efficient tablet formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If flow agents or binder agents are added to cannabinoid to form tablets, then tablet formation becomes easier, but purity and particle size distribution of the cannabinoid deteriorate
Solution Approach 1:
The patent removes flow agents and binder agents from the tablet formulation, extracting the problematic additives that compromise purity and particle size distribution. The cannabinoid is pressed into tablets in its pure form, eliminating contamination from excipients while maintaining manufacturability through optimized pressing parameters and particle size control.
Solution Approach 2:
The patent changes physical parameters of the cannabinoid material, specifically controlling particle size distribution within a defined range and adjusting moisture content, to enable direct compression into tablets without additives. These parameter modifications allow the pure cannabinoid to achieve adequate flow and compression properties for tablet formation.
2Ease of manufacture
If flow agents or binder agents are used in cannabinoid dosage forms, then manufacturing process becomes simpler, but dosing accuracy and precision deteriorate
Solution Approach 1:
The patent eliminates flow agents and binder agents from the formulation, removing substances that can interfere with dosing accuracy. By using pure cannabinoid material with controlled particle size and moisture content, the patent achieves both manufacturing feasibility and precise dosing without excipient-related variability.
3Ease of manufacture
If additional additives are mixed with cannabinoid, then tablet formation improves, but cannabinoid purity deteriorates
Solution Approach 1:
The patent extracts and eliminates all additional additives including flow agents and binder agents from the tablet formulation. The final product consists solely of cannabinoid material with controlled physical properties, ensuring maximum purity while achieving tablet formation through non-additive methods.
Solution Approach 2:
The cannabinoid material itself provides the necessary properties for tablet formation through controlled particle size distribution and moisture content, without requiring external additives. The material serves its own function of enabling compression and tablet formation, eliminating the need for excipients that would compromise purity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables the creation of accurate and precise dosage forms of cannabinoids, ensuring consistent purity and particle size, which facilitates predictable treatment outcomes and avoids the need for additional additives.
Implementation Method 1
disposing an amount of cannabinoid, such as crystalline cannabidiol, in a pill press and operating the pill press to form cannabinoid tablets
Data Source
AI summary
A dosage form containing an amount of cannabidiol pressed into a tablet.