Fast Disintegrating Cannabinoid Tablet Formulation
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Solution Overview
Problem
Current cannabinoid delivery methods, particularly tablets, face challenges in achieving fast and controlled release while maintaining beneficial sensoric properties such as friability, texture, flavor perception, and minimizing off-notes, which are crucial for effective and comfortable administration.
Innovation Solution
A fast disintegrating cannabinoid tablet formulation comprising sugar alcohol particles, cannabinoids, and disintegrants that reversibly associate with each other, allowing for rapid disintegration within 2 minutes under saliva contact, thereby providing a quick and controlled release of cannabinoids without significant off-notes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If conventional tablet formulations are used for cannabinoid delivery, then the tablet structure provides stability and ease of manufacture, but the release of cannabinoids is slow and off-notes are prominent
Solution Approach 1:
The tablet is formulated with multiple discrete components including sugar alcohol particles, disintegrants, and cannabinoids that segment and separate rapidly upon contact with saliva, enabling fast release of cannabinoids while preventing prolonged exposure that causes off-notes
Solution Approach 2:
The formulation changes the physical and chemical parameters of the tablet matrix by using specific sugar alcohols and disintegrants that alter the dissolution rate and release profile of cannabinoids, achieving rapid release within 2 minutes while minimizing off-notes through controlled parameter optimization
2Loss of time
If the tablet is designed for fast disintegration, then the delivery of cannabinoids is rapid and effective, but the structural integrity and hardness of the tablet are compromised
Solution Approach 1:
Disintegrant particles are pre-distributed throughout the tablet matrix during formulation, creating predetermined weak points that facilitate rapid breakdown upon saliva contact while maintaining adequate structural integrity during storage and handling
Solution Approach 2:
The tablet uses a composite formulation combining sugar alcohols, disintegrants, and cannabinoids where each component contributes different properties - the sugar alcohol provides structure, the disintegrant enables fast breakdown, and the cannabinoid is released rapidly, achieving both strength and fast disintegration
3Quantity of substance
If the tablet contains high concentration of cannabinoids for effective treatment, then the therapeutic effect is enhanced, but the off-notes and adverse sensoric properties increase
Solution Approach 1:
Sugar alcohol particles and disintegrants act as intermediary substances that interact with cannabinoids during the disintegration process, facilitating rapid release and dilution in saliva, which reduces the concentration of off-notes in the oral cavity while maintaining effective therapeutic delivery
Solution Approach 2:
The formulation uses parameter changes in the release profile to deliver high cannabinoid concentrations rapidly and then quickly dilute them through saliva, transforming the sensoric experience from prolonged exposure to brief, intense delivery that minimizes off-notes while maintaining efficacy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation enables rapid and effective delivery of cannabinoids with improved sensoric properties, enhancing patient compliance and reducing adverse effects by ensuring quick alleviation or treatment response with minimal discomfort.
Implementation Method 1
a disintegrant composition comprising one or more disintegrants operable to disintegrate the tablet within a period of 2 minutes or less in contact with oral saliva
Implementation Method 2
at least a part of the one or more cannabinoids is reversibly associated with at least a part of the one or more sugar alcohol particles by means of adsorption in a premixture
Data Source
AI summary
The present invention relates in a first aspect to a fast disintegrating cannabinoid tablet, the tablet comprising a sugar alcohol composition comprising one or more sugar alcohol particles in an amount of at least 20% by weight of the tablet, a cannabinoid composition comprising one or more cannabinoids, and a disintegrant composition comprising one or more disintegrants operable to disintegrate the tablet within a period of 2 minutes or less in contact with oral saliva. In a second aspect, the invention relates to a modular tablet, wherein the tablet comprises a further tablet module that is different in composition.