Fast Disintegrating Cannabinoid Tablets with Sugar Alcohol
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Solution Overview
Problem
Current cannabinoid delivery methods, particularly tablets, face challenges in achieving fast and controlled release while maintaining beneficial sensorics properties, such as friability, texture, and flavor perception, due to the lipophilic nature of cannabinoids like CBD, which often results in off-notes and reduced patient compliance.
Innovation Solution
A fast disintegrating tablet formulation comprising at least 20% sugar alcohol particles, a cannabinoid composition, and disintegrants that disintegrate within 2 minutes in oral saliva, ensuring rapid and controlled release without significant off-notes, improved sensorics, and enhanced absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If conventional tablet formulations are used for cannabinoid delivery, then the tablets provide structural stability and ease of manufacture, but they disintegrate slowly in oral saliva resulting in delayed release and reduced patient compliance
Solution Approach 1:
The tablet is segmented into multiple functional components: sugar alcohol particles (20-80% w/w) that provide rapid disintegration, disintegrants (5-30% w/w) that facilitate quick breakdown in saliva, and cannabinoid composition (1-20% w/w) that delivers the active ingredient. This segmentation allows the tablet to maintain structural integrity during handling while disintegrating rapidly upon contact with oral saliva.
Solution Approach 2:
The formulation changes key parameters including using sugar alcohols with specific particle size distributions (D10: 50-150 μm, D50: 150-350 μm, D90: 350-750 μm) to optimize both structural stability and disintegration speed. The disintegrant content is optimized at 5-30% w/w to ensure rapid breakdown within 2 minutes while maintaining tablet integrity during storage and handling.
2Quantity of substance
If higher concentrations of cannabinoids are released in tablets, then the therapeutic effectiveness is improved, but off-notes become predominant causing reduced patient compliance
Solution Approach 1:
Sugar alcohol particles serve as an intermediary carrier for the cannabinoid composition. They provide a matrix that controls the release of cannabinoids, allowing higher concentrations (1-20% w/w) to be delivered while the sugar alcohol matrix modulates the release profile to prevent overwhelming off-notes. The disintegrants further mediate this release by controlling the breakdown kinetics in oral saliva.
Solution Approach 2:
The sugar alcohol particles create a porous matrix structure that facilitates controlled cannabinoid release. This porous structure allows saliva penetration and gradual cannabinoid dissolution, preventing sudden high-concentration release that would cause predominant off-notes, while still delivering sufficient therapeutic amounts.
3Ease of operation
If the tablet formulation is optimized for fast disintegration, then patient compliance and convenience are improved, but the sensorics properties such as texture and flavor perception may be compromised
Solution Approach 1:
The formulation uses a composite material system combining sugar alcohols (20-80% w/w), disintegrants (5-30% w/w), and cannabinoid composition (1-20% w/w). This composite structure provides both fast disintegration (improving patient compliance) and maintains favorable sensorics properties. The sugar alcohol matrix specifically contributes to pleasant texture and flavor perception while enabling rapid breakdown in oral saliva within 2 minutes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation provides rapid and controlled release of cannabinoids with improved sensorics properties, increased patient compliance, and effective delivery of cannabinoids, overcoming the limitations of conventional lozenge formulations by balancing disintegration time and absorption speed.
Implementation Method 1
a disintegrant composition comprising one or more disintegrants operable to disintegrate the tablet within a period of 2 minutes or less in contact with oral saliva
Implementation Method 2
disintegrants operable to disintegrate the tablet within a period of 2 minutes or less in contact with oral saliva
Implementation Method 3
a sugar alcohol composition comprising one or more sugar alcohol particles in an amount of at least 20% by weight of the tablet
Implementation Method 4
ensuring rapid and controlled release without significant off-notes, improved sensorics, and enhanced absorption
Data Source
AI summary
The present invention relates in a first aspect to a fast disintegrating cannabinoid tablet, the tablet comprising a sugar alcohol composition comprising one or more sugar alcohol particles in an amount of at least 20% by weight of the tablet, a cannabinoid composition comprising one or more cannabinoids, and a disintegrant composition comprising one or more disintegrants operable to disintegrate the tablet within a period of 2 minutes or less in contact with oral saliva. In a second aspect, the invention relates to a modular tablet, wherein the tablet comprises a further tablet module that is different in composition.