Water-Soluble Cannabinoid Formulations Using Vitamin E TPGS
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Solution Overview
Problem
Current methods of administering cannabinoids fail to take full advantage of their properties, lack control over selecting individual cannabinoids, introduce harmful compounds, and have low bioavailability and permeability into the bloodstream.
Innovation Solution
Development of water-soluble cannabinoid formulations using Vitamin E TPGS in ratios of 1:1 to 1:10 with purified cannabinoids, allowing for increased bioavailability and permeability into the bloodstream.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If cannabinoids are extracted as crude mixtures from cannabis plant, then the extraction process is simple, but the ability to select individual cannabinoids for specific benefits is lost
Solution Approach 1:
The crude cannabinoid mixture is segmented into individual purified cannabinoid compounds through chromatography and other separation techniques. This allows each cannabinoid to be isolated and selected based on its specific therapeutic benefits, resolving the contradiction between extraction simplicity and cannabinoid selection control.
Solution Approach 2:
Individual cannabinoids are extracted and purified from the crude mixture using advanced separation methods. This enables the selection and isolation of specific cannabinoids for targeted therapeutic applications while maintaining a relatively simple overall process flow.
2Ease of operation
If cannabinoids are administered through burning plant matter or vapor inhalation, then administration is simple, but harmful and toxic compounds are introduced into the body
Solution Approach 1:
Cannabinoids are extracted and purified from the plant matrix, separating them from harmful combustion byproducts and toxic compounds. This allows for administration of pure cannabinoids through safer routes such as oral ingestion or sublingual delivery, eliminating the need for burning or vaporization.
Solution Approach 2:
The physical and chemical parameters of cannabinoid delivery are changed from combustion-based (high temperature, oxidative environment) to purified extract-based delivery (controlled dissolution, neutral pH). This parameter change eliminates harmful combustion products while maintaining ease of administration.
3Ease of manufacture
If traditional cannabinoid formulations are used, then formulation process is straightforward, but bioavailability and permeability into bloodstream are low
Solution Approach 1:
Cyclodextrins are used as intermediary molecules that form inclusion complexes with purified cannabinoids. This intermediary structure enhances the solubility, stability, and bioavailability of cannabinoids in aqueous environments while maintaining straightforward formulation processes. The cyclodextrin acts as a carrier that facilitates bloodstream permeability.
Solution Approach 2:
The formulation creates a composite system combining purified cannabinoids with cyclodextrin carriers and other excipients. This composite material exhibits enhanced bioavailability and permeability properties compared to pure cannabinoids alone, while keeping the formulation process relatively simple through standardized manufacturing steps.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Provides aqueous formulations with enhanced bioavailability and permeability of cannabinoids, offering controlled administration and reduced harmful compounds.
Implementation Method 1
compositions comprising a first purified cannabinoid and Vitamin E TPGS... Disclosed herein are new cannabinoid formulations, including water soluble cannabinoid formulations
Implementation Method 2
provides increased bioavailability of cannabinoids... aqueous cannabinoid formulations
Data Source
AI summary
This disclosures relates to new compositions and methods for making cannabinoid formulations. In one embodiment, this disclosure provides water soluble compositions comprising a first purified cannabinoid and Vitamin E TPGS. In one embodiment, the disclosure herein comprises a method of making powders comprising heatings material to a first temperature and a second temperature.