Modulating Cannabis Cannabinoid Ratios to Reduce Side Effects
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Solution Overview
Problem
Current cannabis varieties have high concentrations of THC, leading to undesirable side effects such as decreased short-term memory, dry mouth, and increased anxiety, which limits their medical and recreational acceptance.
Innovation Solution
Development of specialty cannabis plants with modulated THC concentrations and varying concentrations of non-THC cannabinoids, terpenoids, and terpene profiles to reduce negative side effects and enhance medical benefits.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If cannabis varieties with high THC concentrations are used, then medical benefits and recreational effects are enhanced, but negative side effects such as decreased short-term memory, dry mouth, and increased anxiety occur
Solution Approach 1:
The patent applies parameter changes by modulating THC concentrations to specific ranges (0.1-10% in some embodiments, 1-5% in others) rather than using high concentrations. It simultaneously adjusts ratios of other cannabinoids (CBD, CBG, CBC) and terpenoids to achieve optimal therapeutic effects while minimizing adverse reactions like anxiety and memory impairment
Solution Approach 2:
The invention creates composite cannabis compositions with balanced profiles of multiple cannabinoids and terpenoids. Specifically, it combines THC with CBD (0.1-10% ratio), CBG (0.1-5%), CBC (0.1-5%), and various terpenoids in controlled proportions to produce synergistic effects that enhance medical benefits while reducing harmful side effects
2Productivity
If traditional cannabis breeding programs are used, then production volume increases, but variety distinction becomes difficult due to promiscuous crosses
Solution Approach 1:
The patent segments the cannabis breeding process into controlled parental selections with distinct genetic lineages. It maintains separate breeding lines for sativa, indica, and hybrid varieties, each with defined cannabinoid and terpene profiles, preventing promiscuous crosses while enabling scalable production of variety-specific products
Solution Approach 2:
The invention uses parameter changes by establishing specific cannabinoid ratio ranges and terpene profile characteristics as defining parameters for each variety type. This allows production scaling while maintaining variety distinction through measurable chemical parameters rather than relying solely on morphological traits
Data Source
AI summary
The invention provides compositions and methods for the breeding, production, processing and use of specialty cannabis.