Cannabis Extract Composition Suppressing MMP-2 and MMP-9 Enzymes
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Solution Overview
Problem
Current cancer treatments, particularly chemotherapy, often result in significant side effects and fail to effectively prevent cancer metastasis without causing drug resistance, as they act non-specifically on the body and have limited specificity for cancer cells.
Innovation Solution
A cannabis extract composition, including cannabinoids and terpenes, is developed to suppress cancer metastasis by inhibiting MMP-2 and MMP-9 enzymes, reducing cancer cell viability, and minimizing side effects during systemic administration, potentially used in functional foods, skin preparations, or medicaments.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If chemotherapy is administered systemically, then cancer cells are targeted throughout the body, but side effects increase due to non-specific action on healthy tissues
Solution Approach 1:
The patent applies local quality by formulating the cannabis extract composition with specific ratios of cannabinoids (THC, CBD, CBC) and terpenes to create a composition that selectively targets cancer cells while sparing healthy tissues. The composition's specific chemical properties enable it to interact differently with cancerous versus normal cells, achieving localized therapeutic effect systemically administered.
Solution Approach 2:
The patent uses composite materials by combining multiple cannabis extract components (THC, CBD, CBC, and terpenes) in a specific formulation. This composite composition works synergistically to enhance anti-cancer activity while reducing individual component toxicity, thereby improving the therapeutic index and reducing side effects compared to single-compound chemotherapies.
2Reliability
If conventional chemotherapeutic agents are used, then cancer cell proliferation is inhibited, but drug resistance develops over time
Solution Approach 1:
The patent applies parameter changes by utilizing the unique pharmacokinetic and pharmacodynamic properties of cannabis compounds. The composition achieves sustained anti-cancer activity through multiple mechanisms (apoptosis induction, cell cycle arrest, metastasis inhibition) that act on different cellular parameters simultaneously, making it difficult for cancer cells to develop resistance through single-pathway adaptation.
Solution Approach 2:
The patent converts the traditionally harmful psychoactive effects of THC into a therapeutic benefit by using it in combination with CBD and CBC. This combination modulates THC's activity to enhance anti-cancer effects while reducing psychoactive side effects, creating a sustainable treatment approach that maintains efficacy without the severe toxicity that limits long-term conventional chemotherapy use.
3Productivity
If high doses of chemotherapeutic drugs are administered, then cancer cell killing increases, but toxicity to healthy organs increases
Solution Approach 1:
The patent applies partial action by using moderate doses of multiple cannabis compounds rather than high doses of a single chemotherapeutic agent. The composition achieves effective cancer cell killing through the cumulative and synergistic action of THC, CBD, CBC, and terpenes, each contributing different anti-cancer mechanisms at lower individual concentrations, thereby reducing organ toxicity while maintaining high productivity in cancer cell elimination.
Data Source
AI summary
The present invention relates to a method of making a cannabis extract composition comprising a cannabis extract as an active ingredient to reduce anti-cancer side effects and suppress cancer metastasis during internal use and administration by suppressing the activity of MMP-2 and MMP-9.