Cannabis Nano-Formulation for Consistent Drug Delivery
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current cannabis products face concerns over side effects and addiction, and existing delivery systems fail to provide consistent and effective delivery of active agents at lower doses.
Innovation Solution
A formulation comprising natural cannabis material, solvent, and stabilizer, forming a liquid suspension with particle sizes below 500 nm, enhancing absorption and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cannabis delivery systems are used, then the active agents can be delivered to patients, but the delivery is inconsistent and requires higher doses to achieve pharmacological effects
Solution Approach 1:
The cannabis material is ground into fine particles with a maximum size of 500 micrometers, creating a segmented structure that increases surface area and improves dissolution. This segmentation allows for more consistent and reliable delivery of active agents, reducing the dose required to achieve pharmacological effects
Solution Approach 2:
The patent changes the particle size parameter of cannabis material to a maximum of 500 micrometers and maintains specific pH ranges (6.0-8.0 for aqueous phases, 4.0-6.0 for alcoholic phases). These parameter changes optimize dissolution and absorption, improving delivery consistency and reducing required doses
2Reliability
If cannabis products are used to treat medical conditions, then pharmacological effects can be achieved, but concerns arise regarding side effects and addiction
Solution Approach 1:
The patent optimizes pH parameters (6.0-8.0 for aqueous, 4.0-6.0 for alcoholic phases) and particle size (≤500 μm) to enhance dissolution and absorption efficiency. This allows lower doses to achieve the same pharmacological effect, thereby reducing potential side effects and addiction risks
Solution Approach 2:
The patent uses food-grade excipients and stabilizers as intermediaries to improve the safety and tolerability of cannabis products. These additives help maintain formulation stability and reduce gastrointestinal irritation, allowing for safer administration
3Reliability
If cannabis material is processed into fine particles, then absorption and dissolution are improved, but the complexity of the formulation process increases
Solution Approach 1:
The cannabis material is segmented into fine particles (≤500 μm) through grinding, which improves dissolution and absorption. This segmentation is achieved using standard pharmaceutical equipment, balancing improved reliability with manageable process complexity
Solution Approach 2:
Food-grade excipients and stabilizers are introduced as intermediaries to simplify the formulation process. These additives facilitate particle suspension and dissolution without requiring complex processing equipment or procedures
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation ensures safer and more effective delivery of cannabis compounds, providing consistent pharmacological effects at lower doses for treating various medical conditions.
Implementation Method 1
a formulation comprising at least one natural cannabis material, at least one solvent, and at least one stabilizer, wherein the formulation is a liquid suspension having a particle size (D 90) of below 500 nm
Data Source
Figure 1
Figure 2
AI summary
The present application relates to a formulation comprising at least one natural cannabis material, at least one solvent, and at least one stabilizer, wherein the formulation is a liquid suspension having a particle size (D90) of below 500 nm, and the use thereof in the treatment of a disease.