Temperature-Responsive Polymeric Wall for Cannabis Dosage Forms
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Solution Overview
Problem
Current cannabis dosage forms for smoking, vaporization, and inhalation lack controlled temperature-dependent release mechanisms, leading to inefficient delivery and handling issues.
Innovation Solution
A temperature-dependent release dosage form comprising a cannabis active material encapsulated within a polymeric wall made of gellable polyols, such as agar, which prevents passage at lower temperatures and allows release at higher temperatures, ensuring controlled delivery and improved handling.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cannabis compounds are delivered without temperature-dependent control, then delivery simplicity is maintained, but release control and efficacy are poor
Solution Approach 1:
The patent applies parameter changes by utilizing the temperature-sensitive solubility characteristics of gellable polyols. The polymeric wall material changes its physical state based on temperature parameters - remaining intact at lower temperatures to prevent release and becoming soluble at higher temperatures to enable controlled release of cannabis compounds, thus achieving reliable temperature-dependent release control
Solution Approach 2:
The patent employs composite materials by formulating a polymeric wall composed of gellable polyols combined with cannabis compounds. This composite structure integrates the temperature-responsive properties of gellable polyols with the active cannabis ingredients, creating a unified dosage form that provides both structural integrity and controlled release functionality
2Ease of operation
If cannabis compounds are released at all temperatures, then ease of delivery is improved, but handling integrity and controlled release are compromised
Solution Approach 1:
The gellable polyol-based polymeric wall exhibits parameter changes in response to temperature variations. During handling at ambient temperatures, the polymeric wall maintains its structural integrity and prevents premature release. Upon exposure to elevated temperatures during vaporization or smoking, the polymeric wall becomes soluble and releases the cannabis compounds, thus achieving both handling convenience and composition stability
3Productivity
If conventional smoking methods are used with crude cannabis, then simplicity is maintained, but delivery efficiency and controlled release are poor
Solution Approach 1:
The patent improves delivery efficiency by formulating a composite dosage form where cannabis compounds are encapsulated within a gellable polyol-based polymeric wall. This composite structure enables controlled release upon heating, significantly improving the efficiency of active ingredient delivery compared to conventional crude cannabis smoking, while maintaining relatively simple manufacturing processes
Solution Approach 2:
The invention utilizes parameter changes in the polymeric wall material's solubility characteristics to achieve controlled release. The gellable polyol remains insoluble at handling temperatures but becomes soluble at vaporization temperatures, enabling efficient and controlled delivery of cannabis compounds without complex manufacturing requirements
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The dosage form ensures controlled release of cannabis compounds at elevated temperatures, enhancing efficacy and user convenience by maintaining integrity during handling and facilitating efficient vaporization or inhalation.
Implementation Method 1
said polymeric wall comprises a gellable polyol, wherein said wall is configured to prevent passage of said active material therethrough at temperatures lower than 45° C.
Implementation Method 2
said wall is configured to allow passage of said active material therethrough at temperatures higher than 80° C.
Data Source
AI summary
Embodiments of the disclosure relate to dosage forms intended for smoking, vaporization and/or inhalation and to methods for the preparations thereof.