Capillary Array Temperature Control via Direct Thermal Contact
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Solution Overview
Problem
Capillary electrophoresis apparatuses face challenges in rapidly controlling capillary temperature, leading to reduced analysis throughput and inconsistent electrophoretic separation due to heat diffusion through intermediate sheets, which affects the separation speed and performance of samples.
Innovation Solution
Direct contact between the capillary substrate and a temperature-controlled member allows for rapid and accurate temperature stabilization of the capillaries, ensuring consistent electrophoretic speed and improved analysis performance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Temperature
If heat is generated by the heater and diffuses through the sheet to reach the capillary, then the capillary can be heated, but the temperature control speed is slow
Solution Approach 1:
The patent introduces a heat-conducting member as an intermediary between the heater and the capillary. This member is specifically designed to have high thermal conductivity, allowing efficient heat transfer from the heater to the capillary while enabling rapid temperature control. The heat-conducting member serves as an optimized thermal bridge that resolves the contradiction between effective heating and fast temperature response.
2Stability of the object's composition
If the capillary is in contact with the heater through a sheet, then the heater can warm the capillary, but the temperature stabilization takes too long
Solution Approach 1:
The heat-conducting member acts as a specialized intermediary that dramatically improves thermal coupling between the heater and capillary. Its high thermal conductivity ensures rapid heat transfer and quick temperature stabilization, reducing the time required to reach the predetermined temperature while maintaining temperature stability during operation.
3Productivity
If the capillary temperature is not controlled rapidly, then the electrophoretic separation can proceed, but the separation speed becomes inconsistent
Solution Approach 1:
The heat-conducting member provides reliable and consistent temperature control to the capillary, which is critical for maintaining stable electrophoretic separation conditions. By ensuring rapid and accurate temperature stabilization, the system achieves both high analysis throughput and consistent separation performance, resolving the contradiction between productivity and reliability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Rapid temperature control of capillaries enhances the stability and efficiency of electrophoretic separation, improving the overall performance and throughput of the analysis process.
Implementation Method 1
the surface of a substrate on which plural capillaries are arranged is in contact with a member that can be controlled for the temperature thereby controlling the temperature of the capillary
Implementation Method 2
a capillary array electrophoresis apparatus includes, basically, a capillary array having a plurality of capillaries, a power supply for applying a high voltage on both ends of the capillary
Data Source
AI summary
In a case where the temperature of capillaries cannot be controlled rapidly in accordance with the change of the amount of heat generated from the capillaries, the phoretic speed of the sample is not controlled constant to lower the analyzing performance for the sample. This invention intends to stabilize the electrophoretic speed. The surface of a substrate on which a plurality of capillaries are arranged is in contact with a member capable of temperature control thereby controlling the temperature of the capillaries. Since a member capable of controlling the temperature and the capillaries are in direct contact with each other according to the invention, the temperature of the capillary can be controlled rapidly at a high accuracy, so that electrophoretic speed is stabilized.