Capillary Sensor Chip for Direct Blood Temperature and Glucose Measurement

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Existing biosensor systems struggle to accurately measure analyte concentration due to temperature variations in the environment, as the temperature of the measuring device does not accurately reflect the temperature of the blood sample, leading to measurement errors.

Innovation Solution

A biosensor system with a sensor chip that includes separate temperature and glucose measurement systems, using a capillary structure with insulating properties and direct current voltage application to temperature electrodes, allowing direct blood sample temperature measurement without hematocrit interference, and correcting analyte concentration based on direct temperature measurement.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If a temperature sensor is disposed in the measuring device to measure reaction temperature, then the temperature measurement function is provided, but the measured temperature does not accurately reflect the blood sample temperature due to environmental temperature differences

Engineering Contradiction:

Improvetemperature measurement accuracyVSAvoidtemperature reflection accuracy

Core Design Contradiction:

Measurement precisionVSReliability

Solution Approach 1:

A heat conduction member is introduced as an intermediary between the blood sample retention unit and the temperature sensor. This heat conduction member efficiently transmits heat from the blood sample to the temperature sensor, ensuring that the sensor accurately reflects the blood sample temperature rather than environmental temperature, thus resolving the contradiction between measurement function and temperature reflection accuracy

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The temperature measurement function is extracted from the main measuring device and integrated directly into the sensor chip. By disposing the temperature sensor and heat conduction member within the sensor chip structure, the system directly measures blood sample temperature at the point of analysis, eliminating the influence of environmental temperature variations in the measuring device

Inventive Principle:

Principle #2Taking out (Extraction)

2Stability of the object's composition

If the measuring device maintains its internal temperature, then device stability is improved, but it cannot track sharp variations in environmental temperature

Engineering Contradiction:

Improvemeasuring device temperature stabilityVSAvoidenvironmental temperature tracking

Core Design Contradiction:

Stability of the object's compositionVSAdaptability or versatility

Solution Approach 1:

The temperature measurement system is segmented into two independent parts: the measuring device maintains its internal temperature stability while the sensor chip independently measures the blood sample temperature. This segmentation allows the device to remain stable while the sensor adapts to the actual sample temperature, resolving the contradiction between device stability and environmental temperature tracking

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The blood sample itself serves as the temperature source for measurement. By using the heat conduction member to transmit heat from the blood sample directly to the temperature sensor, the system allows the sample to 'self-report' its temperature, eliminating the need for the measuring device to track environmental temperature changes

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach improves the accuracy of analyte concentration measurement by directly measuring blood sample temperature, reducing environmental temperature-induced errors and enhancing measurement precision.

Implementation Method 1

a heat conduction member in proximity to the blood sample retention unit of the sensor chip, and detects the temperature of the blood sample transmitted through the heat conduction member

Methodology Applied

Scientific EffectHeat conduction: Conduction (thermal)

Implementation Method 2

the capillary is formed by an insulating plate, a spacer and a cover

Methodology Applied

Scientific EffectThermal insulation: Thermal Insulation

Implementation Method 3

a biosensor system with a sensor chip that includes separate temperature and glucose measurement systems, using a capillary structure with insulating properties and direct current voltage application to temperature electrodes, allowing direct blood sample temperature measurement without hematocrit interference

Methodology Applied

Scientific EffectElectrical resistance temperature measurement: Electrical Resistance

Data Source

PatentEP3301439B1Sensor chip for measuring glucose and temperature of a blood sample

Publication Date: 2025.09.17 PHC HLDG CORP

Figure 1
Figure 2
Figure 3

AI summary

A sensor chip (200) includes a measuring unit (41) and a measuring unit (42). The measuring unit (41) includes an electrode system (temperature electrodes) having a portion (31) of an electrode (11) and a portion (32) of an electrode (12), and a portion of a capillary (40) containing the portion (31) and the portion (32). The measuring unit (42) includes an electrode system (analysis electrodes) having a portion (33) of a sensor electrode (13) and a portion (34) of an electrode (14), and a portion of a capillary (40) containing the portion (33) and the portion (34) in addition to a reaction reagent layer (20). Data (a) related to the temperature of the blood sample is acquired based on the dimension of a current flowing through the temperature electrodes, and data (b) related to a concentration of an analyte in the blood sample is acquired based on the dimension of a current flowing through the analysis electrodes.