Capillary Anticoagulant Coating via Colloidal Evaporation
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Solution Overview
Problem
Current methodologies for coating the inner surfaces of liquid test sample dispensing devices with anticoagulants, such as heparin, often result in the formation of crystalline or solid granular plugs that obstruct the flow of liquid samples, hindering the intake and outflow and reducing the hold time of the sample before coagulation.
Innovation Solution
A method involving the use of a colloidal solution containing an anticoagulant and an insoluble volatile compound, which is wicked into the capillary and then heated to evaporate the solvent, leaving uniform anticoagulant granules that are melted to form a continuous, non-obstructive coating on the inner surface of the capillary.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current coating methodologies are used to coat the inner surface of the capillary with anticoagulant compound, then the anticoagulant coating is applied, but crystalline or solid granular plugs form that obstruct liquid sample flow
Solution Approach 1:
The patent changes the physical-chemical parameters of the coating process by using a colloidal solution instead of traditional coating methods. The colloidal nature of the solution allows for uniform distribution of anticoagulant particles at the molecular level, preventing crystalline plug formation while maintaining effective anticoagulant coating on the capillary inner surface.
Solution Approach 2:
The patent introduces an intermediary carrier system (colloidal solution with insoluble volatile compound) that mediates the deposition of anticoagulant compound. The volatile compound acts as a temporary carrier that evaporates uniformly, leaving behind a uniform anticoagulant coating without forming obstructive crystalline structures.
2Duration of action of moving object
If anticoagulant compound is coated on the capillary inner surface, then coagulation is prevented, but the formation of plugs inhibits sample intake and outflow
Solution Approach 1:
The patent modifies the deposition parameters by using colloidal suspension and controlled evaporation, transforming the coating from a granular crystalline structure to a uniform molecular-level coating. This parameter change maintains anticoagulant effectiveness while eliminating flow obstruction.
Solution Approach 2:
The patent achieves uniform local quality of coating distribution throughout the capillary inner surface. The colloidal solution ensures that anticoagulant compound is evenly distributed at all locations, preventing localized plug formation while maintaining consistent anticoagulant protection along the entire sample path.
3Quantity of substance
If traditional coating methods are used, then anticoagulant is deposited, but the coating is non-uniform and obstructive
Solution Approach 1:
The patent changes the physical state and distribution parameters of the anticoagulant compound by dissolving or suspending it in a colloidal solution. This parameter change enables uniform deposition at the molecular level, achieving precise and consistent coating thickness throughout the capillary inner surface.
Solution Approach 2:
The patent replaces mechanical coating methods (which create uneven granular deposits) with a chemical-colloidal deposition system. The colloidal solution naturally distributes particles uniformly through Brownian motion and capillary action, eliminating the need for complex mechanical application while achieving superior coating uniformity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach prevents the formation of plugs, ensuring unobstructed sample flow and increasing the hold time of the liquid sample within the device before coagulation, thereby enhancing the efficiency of diagnostic assays.
Implementation Method 1
a volume of the colloidal solution enters into and is retained within the capillary via the opening
Implementation Method 2
heating at least the capillary portion of the liquid test sample dispensing device to a temperature wherein the at least one insoluble volatile compound evaporates from the colloidal solution contained within the capillary
Implementation Method 3
heating the granules of the at least one anticoagulant compound to a temperature that melts the granules and thereby forms a uniform coating of the at least one anticoagulant compound on the at least one inner surface of the capillary
Data Source
AI summary
Methods, devices, and kits, related to embodiments for uniformly coating at least one inner surface of a capillary with at least one anticoagulant compound.