Capillary Microextraction Tube Injection Method
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Solution Overview
Problem
Traditional sample pretreatment methods for liquid samples are time-consuming, complex, and require large amounts of organic solvents, limiting their efficiency and environmental sustainability.
Innovation Solution
A microextraction tube injection method using a capillary tube filled with an organic solvent, where a sample is passed through the tube, analytes are extracted and dissolved in the solvent, and the solution is directly injected into a gas chromatography system, eliminating the need for solvent concentration and reducing solvent usage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional sample pretreatment methods (soxhlet extraction, liquid-liquid extraction) are used, then extraction and purification can be achieved, but processing time is long and operation is complex
Solution Approach 1:
The patent combines extraction, purification, and concentration functions into a single microextraction tube operation. The microextraction tube integrates the adsorbent material directly in the injection port, allowing simultaneous extraction and concentration of analytes from the sample matrix without requiring separate processing steps for each function.
Solution Approach 2:
The microextraction tube serves multiple functions: it acts as the extraction medium, the purification filter, and the concentration device all in one component. This multi-functional design eliminates the need for separate cartridges, filtration steps, and concentration procedures required by traditional methods.
2Quantity of substance
If traditional sample pretreatment methods are used, then target compounds can be extracted, but organic solvent consumption is large
Solution Approach 1:
The patent extracts the essential extraction function from the complex traditional system and concentrates it into the microextraction tube containing adsorbent material. This eliminates the need for large volumes of organic solvents used in liquid-liquid extraction while maintaining effective analyte extraction through solid-phase adsorption mechanisms.
Solution Approach 2:
The invention changes the extraction mechanism from solvent-based liquid-liquid extraction to adsorbent-based solid-phase extraction. This parameter change from liquid solvent to solid adsorbent fundamentally reduces organic solvent consumption while improving extraction efficiency for target compounds.
3Reliability
If SPE cartridges are used for liquid sample extraction, then purification can be achieved, but the procedure is complex and requires multiple steps
Solution Approach 1:
The patent merges the SPE cartridge function with the injection system by placing the microextraction tube directly in the injection port. This integration eliminates the need for separate loading, washing, and elution steps required by traditional SPE cartridges, simplifying the procedure while maintaining purification quality.
4Measurement precision
If nitrogen blowing concentration is used to improve sensitivity, then analyte concentration can be increased, but processing time increases and operation complexity increases
Solution Approach 1:
The microextraction tube performs automatic in-situ concentration of analytes as the sample passes through it. The adsorbent material in the tube automatically concentrates the analytes from the sample matrix without requiring external concentration operations like nitrogen blowing, achieving both time savings and maintained sensitivity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method integrates separation, enrichment, and injection, improving efficiency, reducing measurement errors, and achieving higher enrichment factors with significantly less organic solvent usage, making it more environmentally friendly and suitable for small volume samples.
Implementation Method 1
The principle of SPE is based on solid-phase adsorption, and target compounds are separated from interfering substances through selective adsorption of the target compounds or interfering substances
Implementation Method 2
filling the capillary micro-extraction tube with an organic solvent and keeping the filling for a certain period of time, so that the extracted analyte is dissolved in the organic solvent inside the capillary micro-extraction tube to form an injection solution
Data Source
AI summary
Disclosed is a sample pretreatment method of microextraction tube injection, comprising providing a capillary micro-extraction tube with extracting medium in it as an injector, passing a sample through the capillary micro-extraction tube, during which an analyte is extracted into an extracting medium inside the capillary micro-extraction tube; then, filling the capillary micro-extraction tube with an organic solvent and keeping the filling for a certain period of time, so that the extracted analyte is dissolved in the organic solvent inside the capillary micro-extraction tube to form an injection solution; finally, keeping one end of the capillary micro-extraction tube sealed and inserting the other end directly into an injection port of a gas chromatography, such that the injection solution is automatically ejected out from the capillary micro-extraction tube into the injection port.