Capillary-Loaded Circular Wafer for Portable Biological Imaging
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Solution Overview
Problem
Conventional biological imaging systems are expensive, require manual analysis, and do not scale well for high-population applications, often providing inaccurate or incompatible results due to their reliance on expensive optics and manual handling.
Innovation Solution
A compact, portable wafer design featuring a pair of circular discs with a gap for carrying biological samples, utilizing capillary action to load samples and potentially containing stains or dyes, which can be imaged using a camera in a portable device.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional microscopic setups with expensive optics are used, then imaging accuracy is improved, but cost and device complexity increase significantly
Solution Approach 1:
The patent employs a simple, inexpensive wafer structure with basic optical components (transparent disc, gap, optional cover slip) that can be mass-produced at low cost. The design intentionally avoids expensive, complex optical systems while maintaining sufficient imaging capability for the intended applications, embodying the principle of using simple, disposable-like components rather than complex reusable equipment.
Solution Approach 2:
The patent extracts the essential function of sample holding and imaging from complex microscopic systems. By isolating the core requirements (sample carrier, transparent window for imaging, simple gap structure) and removing unnecessary complex components (expensive optics, complex stage mechanisms, automated analysis systems), the design achieves cost-effective imaging suitable for portable devices.
2Ease of operation
If manual analysis methods are used, then operational flexibility is maintained, but productivity and scalability are limited
Solution Approach 1:
The wafer design incorporates features that enable self-loading of biological samples through capillary action. The gap between the transparent disc and cover slip (or opposing disc) automatically draws in liquid samples without requiring manual manipulation or complex loading mechanisms. This self-service capability maintains operational simplicity while enabling high-throughput processing and scalability.
Solution Approach 2:
The patent replaces manual mechanical manipulation of samples with passive capillary action physics. Instead of requiring operators to manually load, position, and manipulate samples using mechanical tools, the design uses the physical phenomenon of capillary wicking to automatically draw samples into the imaging gap, thereby increasing productivity while maintaining ease of operation.
3Adaptability or versatility
If portable device format is used, then accessibility and scalability are improved, but imaging capability may be compromised
Solution Approach 1:
The patent optimizes specific parameters of the wafer structure to achieve effective imaging within a portable device context. The gap size (controlled by spacer thickness), disc transparency, and sample loading volume are carefully selected to provide sufficient optical path quality for imaging while maintaining a compact form factor. These parameter optimizations enable portable deployment without significant compromise of imaging capability for the intended diagnostic applications.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables efficient, accurate, and cost-effective biological sample imaging by leveraging capillary action for sample loading and a portable imaging setup, improving scalability and reducing manual handling errors.
Implementation Method 1
The gap may be sized to pull a biological sample into the gap by capillary action.
Data Source
AI summary
A wafer for carrying a biological sample includes a pair of circular discs, at least one of the discs being transparent. The wafer also includes a gap between the discs adapted to receive a biological sample. The compact circular shape of the wafer makes it particularly suited for use in a portable device in which the wafer is rotated to enable a camera to image different areas of the sample between the discs. The gap may be sized to pull a biological sample into the gap by capillary action.


