Capillary-Loaded Circular Wafer for Portable Biological Imaging

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Solution Overview

Problem

Conventional biological imaging systems are expensive, require manual analysis, and do not scale well for high-population applications, often providing inaccurate or incompatible results due to their reliance on expensive optics and manual handling.

Innovation Solution

A compact, portable wafer design featuring a pair of circular discs with a gap for carrying biological samples, utilizing capillary action to load samples and potentially containing stains or dyes, which can be imaged using a camera in a portable device.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional microscopic setups with expensive optics are used, then imaging accuracy is improved, but cost and device complexity increase significantly

Engineering Contradiction:
Improveimaging accuracyVSAvoiddevice complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent employs a simple, inexpensive wafer structure with basic optical components (transparent disc, gap, optional cover slip) that can be mass-produced at low cost. The design intentionally avoids expensive, complex optical systems while maintaining sufficient imaging capability for the intended applications, embodying the principle of using simple, disposable-like components rather than complex reusable equipment.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent extracts the essential function of sample holding and imaging from complex microscopic systems. By isolating the core requirements (sample carrier, transparent window for imaging, simple gap structure) and removing unnecessary complex components (expensive optics, complex stage mechanisms, automated analysis systems), the design achieves cost-effective imaging suitable for portable devices.

Inventive Principle:
Principle #2Taking out (Extraction)

2Ease of operation

If manual analysis methods are used, then operational flexibility is maintained, but productivity and scalability are limited

Engineering Contradiction:
Improveoperational flexibilityVSAvoidscalability
Core Design Contradiction:
Ease of operationVSProductivity

Solution Approach 1:

The wafer design incorporates features that enable self-loading of biological samples through capillary action. The gap between the transparent disc and cover slip (or opposing disc) automatically draws in liquid samples without requiring manual manipulation or complex loading mechanisms. This self-service capability maintains operational simplicity while enabling high-throughput processing and scalability.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The patent replaces manual mechanical manipulation of samples with passive capillary action physics. Instead of requiring operators to manually load, position, and manipulate samples using mechanical tools, the design uses the physical phenomenon of capillary wicking to automatically draw samples into the imaging gap, thereby increasing productivity while maintaining ease of operation.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Adaptability or versatility

If portable device format is used, then accessibility and scalability are improved, but imaging capability may be compromised

Engineering Contradiction:
ImproveportabilityVSAvoidimaging capability
Core Design Contradiction:
Adaptability or versatilityVSMeasurement precision

Solution Approach 1:

The patent optimizes specific parameters of the wafer structure to achieve effective imaging within a portable device context. The gap size (controlled by spacer thickness), disc transparency, and sample loading volume are carefully selected to provide sufficient optical path quality for imaging while maintaining a compact form factor. These parameter optimizations enable portable deployment without significant compromise of imaging capability for the intended diagnostic applications.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables efficient, accurate, and cost-effective biological sample imaging by leveraging capillary action for sample loading and a portable imaging setup, improving scalability and reducing manual handling errors.

Implementation Method 1

The gap may be sized to pull a biological sample into the gap by capillary action.

Methodology Applied
Scientific EffectCapillary action: Capillary Action

Data Source

PatentUS11534751B2Wafer for carrying biological sample
Publication Date: 2022.12.27 OXFORD IMMUNE ALGORITHMICS LTD
  • US11534751B2 patent drawing
  • US11534751B2 patent drawing
  • US11534751B2 patent drawing

AI summary

A wafer for carrying a biological sample includes a pair of circular discs, at least one of the discs being transparent. The wafer also includes a gap between the discs adapted to receive a biological sample. The compact circular shape of the wafer makes it particularly suited for use in a portable device in which the wafer is rotated to enable a camera to image different areas of the sample between the discs. The gap may be sized to pull a biological sample into the gap by capillary action.