Capsicum Composition Ratio for Cardiometabolic Syndrome Management

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Solution Overview

Problem

Current capsicum compositions do not effectively characterize specific combinations of capsaicinoids and non-capsaicinoids, such as flavonoids and saponins, in a ratio that exhibits beneficial biological effects, particularly in managing cardiometabolic syndrome and associated cardiovascular risks.

Innovation Solution

Development of capsicum compositions comprising capsaicinoids and non-capsaicinoids in a specific ratio of 1:0.1 to 1:10, including major capsaicinoids like capsaicin and dihydrocapsaicin, and polyphenols like flavonoids, which are identified and quantified using advanced analytical techniques, and prepared using food-grade solvents for safe human consumption.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If capsicum compositions use conventional extraction methods without specific ratio control, then extraction process is simple, but biological efficacy is insufficient

Engineering Contradiction:

Improvebiological efficacyVSAvoidextraction process complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies parameter changes by precisely controlling the ratio of capsaicinoids to non-capsaicinoids (specifically saponins and polyphenols) in the capsicum composition. By optimizing this chemical composition parameter to specific ranges, the invention achieves enhanced biological efficacy for managing cardiometabolic syndrome while maintaining a feasible extraction process using food-grade solvents.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention employs composite materials by creating a capsicum composition that intentionally combines multiple bioactive compounds (capsaicinoids, saponins, and polyphenols) in specific ratios. This composite approach leverages the synergistic effects of different compound classes to achieve superior therapeutic outcomes compared to single-compound preparations.

Inventive Principle:

Principle #40Composite materials

2Reliability

If capsicum compositions focus only on capsaicinoids, then composition is simple, but therapeutic effect is limited

Engineering Contradiction:

Improvetherapeutic effectVSAvoidcomposition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies composite materials by creating a capsicum composition that intentionally combines multiple bioactive compounds (capsaicinoids, saponins, and polyphenols) in specific ratios. This composite approach leverages the synergistic effects of different compound classes to achieve superior therapeutic outcomes compared to single-compound preparations.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The invention applies parameter changes by precisely controlling the ratio of capsaicinoids to non-capsaicinoids (specifically saponins and polyphenols) in the capsicum composition. By optimizing this chemical composition parameter to specific ranges, the invention achieves enhanced biological efficacy for managing cardiometabolic syndrome while maintaining a feasible extraction process using food-grade solvents.

Inventive Principle:

Principle #35Parameter changes

3Manufacturing precision

If advanced analytical techniques are used for composition characterization, then composition precision is improved, but manufacturing complexity increases

Engineering Contradiction:

Improvecomposition characterization precisionVSAvoidmanufacturing process complexity

Core Design Contradiction:

Manufacturing precisionVSDevice complexity

Solution Approach 1:

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The capsicum compositions effectively manage cardiometabolic syndrome by reducing oxidative stress, inflammatory markers, inhibiting pancreatic lipase, and enhancing lipolysis, thereby improving cardiovascular health and associated risk factors like body weight, lipid profiles, and blood glucose levels.

Implementation Method 1

Capsicum compositions described herein can reduce cardiometabolic stress in a subject, in need thereof, by inhibiting pancreatic lipase enzyme and enhancing lipolysis

Methodology Applied

Scientific EffectEnzyme inhibition: Enzyme

Implementation Method 2

The composition also improves cardiovascular endothelial function by reducing oxidative stress and inflammatory markers

Methodology Applied

Scientific EffectAntioxidant activity: Oxidation

Data Source

PatentUS10668123B2Capsicum compositions and uses thereof

Publication Date: 2020.06.02 OMNIACTIVE HEALTH TECH LTD

AI summary

Capsicum compositions are described that include biologically active constituents non-capsaicinoids and capsaicinoids in a specific ratio are useful for the treatment and management of cardiometabolic syndrome and associated risk factors, in a subject in need thereof. The capsicum compositions include a capsicum extract which is prepared by extracting capsicum pods by using suitable polar and non-polar solvents. Capsicum compositions include non-capsaicinoid components like saponins and polyphenols such as flavonoids, which along with capsaicinoids effectively reduce risk factors of cardiometabolic syndrome and also reduce oxidative stress on vital body organs by reducing inflammatory and/or oxidative markers. The capsicum compositions inhibit pancreatic lipase enzyme and enhance lipolysis, when administered in an effective amount to a subject in need thereof. Capsicum compositions as described herein are prepared by human intervention and are safe for consumption.