Pharmaceutical Capsule With Segmented Tablets For Release Control
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Solution Overview
Problem
Current pharmaceutical dosage forms that combine multiple active ingredients are complex to manufacture and often require expensive equipment, making it difficult to produce capsules with separate compartments that can ensure precise control over the release profiles of different active ingredients, particularly for immediate and sustained release matrices.
Innovation Solution
A capsule containing two tablets with different dimensions, made from materials like gelatin or hydroxylpropyl methyl cellulose, where each tablet has a unique composition and release profile, allowing for coordinated therapeutic dosages and easy swallowing, with the option of immediate and sustained release combinations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If separate compartments are used to contain different active ingredients, then precise control over release profiles is improved, but device complexity and manufacturing difficulty increase
Solution Approach 1:
The invention divides the capsule into separate compartments, each containing a different active ingredient with its own release profile. This segmentation allows precise control over the release of each ingredient independently while maintaining a relatively simple overall capsule structure that is easier to manufacture than fully integrated multi-ingredient systems.
2Ease of operation
If multiple active ingredients are combined in a single tablet, then patient compliance is improved, but manufacturing complexity increases
Solution Approach 1:
The invention combines multiple active ingredients into a single capsule dosage form, improving patient compliance by simplifying the administration regimen. While the capsule contains multiple ingredients, the manufacturing process is simplified by using separate compartments rather than complex multi-layer or compressed multi-ingredient tablets, thus achieving the combination benefit without proportionally increasing manufacturing complexity.
3Reliability
If excipients are used in tablet formulations, then therapeutic effectiveness is improved, but capsule size increases due to bulkiness
Solution Approach 1:
The invention uses a capsule shell structure that efficiently contains the excipient-loaded tablets. The capsule shell provides a compact enclosure that minimizes the overall volume required to contain the necessary excipients for therapeutic effectiveness, making the final dosage form suitable for oral ingestion despite the presence of bulky excipient materials.
Data Source
AI summary
The present invention is directed to an oral pharmaceutical dosage form comprising a capsule containing at least two tablets, each tablet containing at least one different pharmaceutically active ingredient