Oral Carbamate Composition With Controlled Particle Size Dissolution

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Solution Overview

Problem

The carbamate compound of Formula 1 exhibits variable dissolution rates and solubility in the in vivo pH range, affecting rapid and consistent therapeutic effects, and micronization affects flowability and stability, complicating uniform dosage control.

Innovation Solution

A pharmaceutical composition with carbamate compound particles of less than 300 μm diameter is used, ensuring rapid and consistent therapeutic effects through controlled particle size and dissolution rate.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If micronization is performed to improve dissolution rate, then dissolution rate is improved, but flowability and stability are worsened

Engineering Contradiction:

Improvedissolution rateVSAvoidflowability and stability

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent applies parameter changes by precisely controlling the particle size distribution parameters (d10, d50, d90) within specific ranges. This optimization of physical parameters achieves rapid dissolution while maintaining adequate flowability and stability, resolving the contradiction between dissolution rate and reliability.

Inventive Principle:

Principle #35Parameter changes

2Productivity

If particle size is reduced to improve dissolution rate, then dissolution rate is improved, but content uniformity is worsened

Engineering Contradiction:

Improvedissolution rateVSAvoidcontent uniformity

Core Design Contradiction:

ProductivityVSManufacturing precision

Solution Approach 1:

The patent controls particle size distribution parameters (d10≥10μm, d50≥20μm, d90≤300μm) to achieve optimal balance between dissolution rate and content uniformity. This parameter optimization ensures rapid dissolution while maintaining manufacturing precision.

Inventive Principle:

Principle #35Parameter changes

3Speed

If injection preparation is used to achieve quick effect, then quick effect is achieved, but ease of operation is worsened

Engineering Contradiction:

Improveonset of actionVSAvoidroute of administration

Core Design Contradiction:

SpeedVSEase of operation

Solution Approach 1:

The patent transforms the pharmaceutical form from injection to oral solid dosage by optimizing particle size distribution parameters. This enables the drug to achieve rapid dissolution and quick effect through oral administration, improving ease of operation while maintaining speed of action.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS20260060922A1Oral pharmaceutical composition comprising carbamate compound and preparation method therefor

Publication Date: 2026.03.05 SK BIOPHARMACEUTICALS CO LTD

AI summary

The present invention relates to an oral pharmaceutical composition comprising a carbamate compound of chemical formula 1, an isomer thereof, or a pharmaceutically acceptable salt, solvate, or hydrate thereof as an active ingredient, and a preparation method therefor.