Cardiac Catheter with Temperature Control for Targeted Therapy
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Solution Overview
Problem
Current treatments for cardiac diseases face challenges in directly targeting the underlying mechanisms of these diseases and are limited by the off-target effects of systemically administered drugs, necessitating a device for precise delivery of therapeutic compounds like genetically engineered vectors or cells, proteins, stem cells, and biologics to the heart.
Innovation Solution
A catheter system with a handle, shaft, and tip portion, featuring a steering element, temperature control, and an actuator for precise delivery of therapeutic compounds to the heart, including genetically engineered vectors or cells, proteins, stem cells, and biologics, capable of targeting specific areas within the heart, such as the sinus node, myocardial infarction scars, or the entire heart.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If therapeutic compounds are administered systemically, then the therapeutic effect is achieved, but off-target effects occur
Solution Approach 1:
The catheter system enables localized delivery of therapeutic compounds directly to the heart tissue through the tip portion, allowing the therapeutic effect to be concentrated at the target site while minimizing exposure to other organs and tissues, thereby reducing off-target effects
2Manufacturing precision
If a catheter system is designed for precise delivery, then delivery accuracy is improved, but device complexity increases
Solution Approach 1:
The catheter system is divided into distinct functional segments including the handle portion for control, the shaft portion for navigation, and the tip portion for delivery, with each segment optimized for its specific function. This segmentation allows for precise delivery capability while managing overall device complexity through modular design
Solution Approach 2:
The catheter system integrates multiple functions into a single device including navigation through the steering element, temperature regulation through the temperature control element, and therapeutic compound delivery through the actuator. This multi-functionality reduces the need for multiple separate devices while maintaining delivery precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise and localized delivery of therapeutic agents to the heart, reducing off-target effects and enhancing treatment efficacy for conditions like conduction system disease, sinus node dysfunction, atrial fibrillation, myocardial infarction, and heart failure, while allowing for temperature control and suction to manage the delivery.
Implementation Method 1
a temperature control element configured to regulate the temperature of a fluid within the fluid pathway
Implementation Method 2
an aspiration pathway disposed within the internal conduit configured to apply suction force from the tip portion to an exterior object
Data Source
AI summary
The present invention relates to a targeted cardiac therapy device that can precisely deliver therapeutic compounds to desired locations on, around or within the heart of a patient, and methods of treating conduction system disease, sinus node dysfunction, atrial fibrillation, myocardial infarction, and heart failure, using the described devices to deliver genetically engineered vectors or cells, proteins, stem cells, small molecule pharmaceuticals and biologics.