Cardiac Repair Prosthesis Set for Aortic Valve and Ascending Aorta

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Solution Overview

Problem

Patients with aortic valve disease and ascending aortic dilation face catastrophic outcomes due to the risks of aortic dissection and rupture during transcatheter aortic valve replacement (TAVI) when concomitant ascending aortic dilatation is present, as current treatments either fail to address both conditions simultaneously or pose significant risks.

Innovation Solution

A cardiac repair prosthesis set comprising a radially expandable support for a unidirectional valve and a blood-impervious stent for the ascending aorta, joined by a biocompatible element, allowing for a single-stage minimally invasive procedure to address both aortic valve and ascending aortic diseases.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If transcatheter aortic valve replacement (TAVI) is performed in patients with concomitant ascending aortic dilatation, then aortic valve disease can be treated, but the risk of catastrophic aortic dissection or rupture increases

Engineering Contradiction:

Improveaortic valve replacement safetyVSAvoidaortic dissection and rupture risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines aortic valve replacement and ascending aortic repair into a single integrated procedure. The prosthesis set includes both a valve replacement component and an aortic repair component that can be deployed simultaneously, eliminating the need for separate procedures and reducing the overall risk exposure to the dilated aorta.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention segments the treatment into modular components: a valve replacement prosthesis and an aortic repair prosthesis. These segmented components can be independently sized and configured, then deployed in a coordinated manner to address both the valve disease and aortic dilatation without requiring the aorta to withstand multiple separate interventions.

Inventive Principle:

Principle #1Segmentation

2Productivity

If isolated TAVI is performed without addressing ascending aortic dilatation, then the aortic valve can be replaced, but patients remain at high risk of spontaneous aortic dissection or rupture

Engineering Contradiction:

Improvetreatment efficiencyVSAvoidaortic disease management completeness

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent merges two previously separate treatments (aortic valve replacement and aortic repair) into a single combined procedure. This allows clinicians to address both the valve disease and aortic dilatation in one intervention, improving treatment completeness without significantly extending procedural time.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The prosthesis set is designed with multi-functionality, where the same delivery system and deployment mechanism can accommodate both valve replacement and aortic repair components. This universal approach allows a single procedure to fulfill multiple therapeutic goals.

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Reliability

If open surgery is performed to replace both the aorta and aortic valve, then both conditions can be treated simultaneously, but the procedure becomes more invasive with higher surgical risk

Engineering Contradiction:

Improvecomprehensive disease treatmentVSAvoidsurgical invasiveness

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent replaces the traditional open surgical mechanical approach with an endovascular delivery system. Both the valve prosthesis and aortic repair prosthesis are delivered through catheters via the femoral artery, eliminating the need for sternotomy and cardiopulmonary bypass while achieving comprehensive treatment of both aortic valve disease and ascending aortic dilatation.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The invention uses an endovascular delivery system as an intermediary to implant both prostheses. This intermediary approach allows the prostheses to be deployed from a remote access point (femoral artery) without requiring direct surgical exposure of the aorta and valve, thereby reducing surgical invasiveness while maintaining treatment effectiveness.

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS10765512B2Cardiac repair prosthesis sets and methods

Publication Date: 2020.09.08 THE TRUSTEES OF THE UNIV OF PENNSYLVANIA

AI summary

Cardiac repair prostheses, sets, and methods for implanting in an aorta are disclosed. Cardiac repair prosthesis sets can include a radially expandable support supporting a unidirectional valve that is configured for implantation into the aortic valve region of a patient and a second radially expandable support for a substantially blood impervious stent having a size and shape for implantation into the ascending aorta of said patient where the unidirectional valve and stent are configured for integration within the patient by at least one joining element. Cardiac repair prostheses can include a radially expandable support supporting a unidirectional valve configured for implantation into the aortic valve region of a patient and a second radially expandable support for a substantially blood impervious stent having a size and shape for implantation into the ascending aorta of said patient where the unidirectional valve and stent are joined by at least one joining element.