Cardiac Risk Visualization Using Non-Invasive Phase Space Tomography
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Solution Overview
Problem
Current methods for visualizing coronary artery blockages and myocardial perfusion are invasive, risky, and provide incomplete information, lacking non-invasive tools for early identification of high-risk patients and preventive strategies.
Innovation Solution
A system that uses phase space tomography analysis and machine-learned predictions to present three-dimensional and two-dimensional visualizations of myocardial tissue, identifying myocardium at risk and coronary artery blockages through a graphical user interface, facilitating non-invasive diagnosis and treatment planning.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If invasive procedures such as coronary angiography are used to measure occlusion size and blood flow, then measurement precision is improved, but patient safety and ease of operation deteriorate due to risks of stroke, heart attack, injury, infection, and radiation exposure
Solution Approach 1:
The patent replaces invasive mechanical catheter-based measurement systems with non-invasive electrical field-based measurement systems. Specifically, it uses body surface potential maps and electrocardiographic signals to infer coronary artery occlusion characteristics and myocardial perfusion status without physical intrusion into the cardiovascular system, thereby eliminating risks associated with catheterization while maintaining diagnostic capability
Solution Approach 2:
The patent introduces electrical fields and computational algorithms as intermediaries to indirectly measure occlusion size and blood flow. Instead of directly measuring these parameters through catheters, the system uses body surface potentials and ECG signals as mediators that contain information about coronary artery status, which are then processed through inverse problem solving and image reconstruction algorithms to derive occlusion characteristics
2Measurement precision
If invasive catheterization procedures are performed to evaluate coronary disease, then diagnostic accuracy is improved, but procedure time and cost increase
Solution Approach 1:
The patent creates a virtual copy of the coronary artery anatomy and physiology through computational modeling and image reconstruction from non-invasive electrical measurements. This virtual model replicates the information obtainable from invasive angiography, allowing diagnostic evaluation without the time-consuming catheterization procedure. The system reconstructs occlusion location and severity from body surface potentials, providing equivalent diagnostic data more quickly
3Loss of information
If comprehensive evaluation of coronary blockage and myocardial perfusion is performed, then information completeness is improved, but device complexity and difficulty of operation increase
Solution Approach 1:
The patent creates a multi-functional diagnostic system that simultaneously evaluates multiple coronary artery parameters (occlusion location, severity, blood flow status) and myocardial perfusion characteristics using a single non-invasive measurement platform. The body surface potential mapping system serves multiple diagnostic purposes concurrently, providing comprehensive information without requiring separate specialized procedures for each parameter
Solution Approach 2:
The patent merges multiple diagnostic functions into a unified computational framework that processes body surface potentials to simultaneously determine coronary artery occlusion characteristics and myocardial perfusion status. The inverse problem solving algorithm integrates information from electrical measurements to reconstruct both vascular anatomy and functional perfusion data in a single integrated process, simplifying the overall diagnostic workflow
Data Source
AI summary
Exemplified methods and systems facilitate presentation of data derived from measurements of the heart in a non-invasive procedure (e.g., via phase space tomography analysis). In particular, the exemplified methods and systems facilitate presentation of such measurements in a graphical user interface, or “GUI” (e.g., associated with a healthcare provider web portal to be used by physicians, researchers, or patients, and etc.) and/or in a report for diagnosis of heart pathologies and disease. The presentation facilitates a unified and intuitive visualization that includes three-dimensional visualizations and two-dimensional visualizations that are concurrently presented within a single interactive interface and/or report.