Cardiovascular Analyzer for Non-Invasive Arterial Stiffness Detection
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Solution Overview
Problem
Current cardiovascular disease diagnosis methods, such as electrocardiographs and imaging technologies, are inadequate for early detection and characterization of coronary artery diseases, particularly in measuring arterial stiffness, compliance, blood flow volume, velocity, and resistance, which are crucial for identifying coronary artery diseases and determining the need for surgery in a non-invasive manner.
Innovation Solution
A cardiovascular analyzer that combines bio-signal measurement systems, including ECG, PCG, and APG sensors, with a processing unit to synthesize the aortic arch internal pressure curve and calculate biodynamic indicators like blood flow volumes, compliances, resistances, and arterial stiffness in left and right coronary arteries, enabling early detection and definition of cardiovascular disease causes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of information
If conventional electrocardiographs are used, then electrical changes in the heart can be recorded, but biodynamic properties of cardiac blood vessels such as elastic coefficient, compliance, and blood flow characteristics cannot be measured
Solution Approach 1:
The patent combines multiple measurement functions into a single integrated system that simultaneously records ECG signals and measures blood flow characteristics, vascular compliance, and elastic coefficients through a unified cardiovascular analyzer platform
Solution Approach 2:
The cardiovascular analyzer is designed to perform multiple diagnostic functions including ECG recording, blood flow velocity measurement, compliance calculation, and elastic coefficient determination, making it a multi-functional device that replaces several separate instruments
2Measurement precision
If invasive testing methods like catheterization are used, then direct observation of blood vessel pathological changes can be achieved, but complex invasive manipulation is required and about 40% of examinees are revealed to be without need of surgery
Solution Approach 1:
The patent replaces invasive mechanical catheterization with non-invasive measurement techniques using external sensors and signal processing to derive blood vessel properties from physiological signals without physical intrusion into the vascular system
Solution Approach 2:
The system uses physiological signals (ECG, blood pressure waves) as intermediaries to indirectly measure blood vessel properties, avoiding direct contact with the vessels while still obtaining accurate compliance and elastic coefficient data through mathematical modeling
3Loss of information
If imaging technologies and angiography are used, then images of cardiac blood vessels can be obtained, but early ischemic diseases and functional analysis cannot be detected
Solution Approach 1:
The patent shifts from structural imaging parameters to functional physiological parameters by measuring blood flow velocity, volume, pressure gradients, and vascular compliance to detect early ischemic changes and functional abnormalities before they manifest as structural changes visible on imaging
4Measurement precision
If SPECT, CE, MDCT, and MRI are used, then coronary artery disease analysis can be performed, but high manufacturing and diagnostic costs limit use to particular hospitals and blood vessel property detection capability is limited
Solution Approach 1:
The patent employs cost-effective sensors and standard medical equipment components that can be widely deployed in常规 hospitals, replacing expensive specialized imaging equipment while providing sufficient diagnostic accuracy for blood vessel property assessment
Solution Approach 2:
The system uses non-invasive external measurements to create functional models of blood vessel properties, effectively copying the diagnostic capability of invasive gold-standard methods without requiring the complex and expensive original equipment
Data Source
AI summary
The present invention relates to a cardiovascular diagnostic system which enables early detection of cardiovascular diseases and defines their causes. Unlike known electrocardiographs, the cardiovascular diagnosis system can further measure elastic coefficient of blood vessels (the degree of arteriosclerosis), blood vessel compliance, blood flow, and blood flow resistance and velocity in blood vessel branches of the right and left coronary arteries. The elastic coefficient shows organic changes to blood vessels. The compliance shows organic and functional changes of blood vessels simultaneously. The blood flow shows blood flow resistance.