Cardiovascular Flow Simulation With Adaptive Pulsatile Pressure Control
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Solution Overview
Problem
Existing simulation systems struggle to accommodate the variability in flow path characteristics of different test members, such as cadavers and synthetic organs, due to differences in physiology, embalming techniques, and presence of blood clots, leading to inconsistent fluid flow simulations.
Innovation Solution
A system comprising a reservoir, input and output channels, valves, and a processor that can modulate fluid flow to achieve a target profile, including pulsatile and systemic resistance components, with real-time adjustment capabilities, and is connectable to various test members to form a fluid circuit.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If simulation systems are connected to different test members (cadavers, synthetic organs), then versatility is improved, but flow path variability causes inconsistent fluid flow characteristics
Solution Approach 1:
The system dynamically adjusts flow parameters in real-time to compensate for variations in test member flow paths. The processor continuously monitors flow characteristics and modulates pump speed and valve positions to maintain target flow profiles despite differences between cadavers and synthetic organs.
Solution Approach 2:
The system changes operational parameters (flow rate, pressure, pulsatility) to adapt to different test members. By modifying these parameters dynamically, the system maintains consistent simulation quality across diverse test members with varying flow path characteristics.
2Device complexity
If simulation systems use fixed flow parameters, then system simplicity is improved, but inability to simulate varying physiological conditions reduces realism
Solution Approach 1:
The system implements periodic pulsatile flow to simulate physiological cardiac cycles. By applying periodic variations in flow rate and pressure, the system creates realistic cardiovascular simulation conditions while maintaining manageable system complexity through standardized pulse patterns.
Solution Approach 2:
The system uses feedback from flow sensors and pressure transducers to automatically adjust flow parameters. This closed-loop control maintains simulation realism by continuously comparing actual flow conditions against target profiles and making real-time corrections.
3Manufacturing precision
If multiple connections are made to test members, then flow control precision is improved, but number of connections increases
Solution Approach 1:
The system uses universal connectors and standardized interface designs that can accommodate different test members with minimal connections. The multi-functional pump and valve system can regulate flow through fewer connection points while maintaining precision control across various cardiovascular simulation scenarios.
Data Source
AI summary
A system for simulating cardiovascular fluid flow having a target fluid flow profile, which has target pulsatile flow and target systemic resistance components, in a test member is disclosed. The system includes a reservoir, a pump, input and output channels, a first valve in the input channel, a second valve in the output channel, and a processor. The input and output channels are connectable to the test member so as to form a fluid circuit with the test member. The processor is configured to execute a method for controlling the first valve to generate the target pulsatile flow component in the input channel, and controlling the second valve to generate the target systemic pressure component. Other systems are also disclosed. Methods for simulating target fluid flow profiles in a test member are also disclosed.