Cardiovascular Waveform Analysis for Proactive Hypotension Prevention

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Solution Overview

Problem

Current methods for monitoring and managing blood pressure during surgical procedures and critical care are reactive and prone to delays, failing to prevent hypotensive episodes effectively, despite the availability of multi-parameter monitors and cardiac output technologies.

Innovation Solution

A system that processes arterial blood pressure waveform data to calculate relative changes in cardiovascular parameters such as cardiac output, systemic vascular resistance, and venous return driving pressure, providing early alerts and treatment recommendations to prevent hypotension.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If multi-parameter monitors and cardiac output technologies are used to monitor blood pressure, then measurement capability is improved, but response time and effectiveness of hypotension prevention deteriorate due to reactive management

Engineering Contradiction:
Improveblood pressure monitoring capabilityVSAvoidresponse time for hypotension prevention
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The system calculates trend values and predicts future blood pressure values before hypotension occurs. By analyzing historical blood pressure data and computing trends, the system provides early warnings that enable proactive intervention rather than reactive response, thus preventing hypotensive episodes before they happen.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system continuously monitors blood pressure, calculates trend values, and provides feedback about the direction and magnitude of blood pressure changes. This feedback loop enables clinicians to adjust treatment in real-time based on predicted trends, transforming passive monitoring into active prevention.

Inventive Principle:
Principle #23Feedback

2Loss of information

If blood pressure is monitored using conventional methods, then current blood pressure values are available, but early warning capability for impending hypotension is lost

Engineering Contradiction:
Improveinformation about future blood pressure trendsVSAvoidhypotension prevention reliability
Core Design Contradiction:
Loss of informationVSReliability

Solution Approach 1:

The system performs preliminary calculations of trend values based on historical blood pressure data. By computing the direction and rate of blood pressure changes before significant hypotension occurs, the system provides advance warning that enables preventive action, thereby recovering the lost information about future blood pressure states.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

Instead of only displaying current blood pressure values, the system inverts the approach by predicting future values based on current trends. This inversion transforms the monitoring paradigm from retrospective (what happened) to prospective (what will happen), enabling early intervention.

Inventive Principle:
Principle #13The other way round (Inversion)

3Productivity

If reactive blood pressure management is used, then treatment is provided after hypotension occurs, but the incidence of hypotension and complications increases

Engineering Contradiction:
Improvetreatment efficiencyVSAvoidincidence of hypotension and complications
Core Design Contradiction:
ProductivityVSObject-affected harmful factors

Solution Approach 1:

The system applies preliminary anti-action by predicting and warning of impending hypotension before it occurs. By providing early warning based on trend analysis, the system enables clinicians to take preventive measures that counteract the development of hypotension, thereby reducing the incidence of hypotensive episodes and associated complications.

Inventive Principle:
Principle #9Preliminary anti-action

Solution Approach 2:

The system performs preliminary assessment of blood pressure trends and provides warnings before hypotension develops. This preliminary action transforms the management approach from reactive treatment to proactive prevention, reducing the harmful effects of hypotension.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentEP4064975B1Cardiovascular analytic system and method
Publication Date: 2025.09.10 DIRECTED SYSTEMS LIMITED
  • EP4064975B1 patent drawingFigure 1~2
  • EP4064975B1 patent drawingFigure 3
  • EP4064975B1 patent drawingFigure 4~5

AI summary

We describe a system for determining relative changes in at least one parameter of cardiovascular function. The system provides an output showing a relative change of the parameters associated with cardiovascular function over a period of time. This relative change is between a time averaged mean of cardiovascular parameters (for each pulse within a series of pulses from an arterial blood pressure waveform data) and a baseline cardiovascular parameter value based on first and second pulses within the blood pressure waveform data. The relative change of the parameters over time is used to project a trend in the parameters associated with cardiovascular function.