Carnauba Wax Polysorbate Coating for Tablet Compression
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Solution Overview
Problem
Conventional coating systems are not suitable for particles designed to be used in compressed tablets, as they become damaged under pressure, exposing the core and active ingredients to external influences.
Innovation Solution
A coating system comprising 50-95% Carnauba wax and 5-50% polysorbate, specifically polysorbate 20, 60, or 80, which provides excellent tablet pressing properties by enhancing the mechanical stability of coated particles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If conventional coating systems are used on particles for compressed tablets, then the coating provides basic protection, but the coated particles are destroyed under compression pressure and the core is exposed to external influences
Solution Approach 1:
The patent applies composite materials by combining Carnauba wax with at least one polysorbate (polysorbate 20, 60, or 80) to create a coating system that exhibits synergistic properties. The Carnauba wax provides structural framework and hardness, while the polysorbate acts as a plasticizer to improve flexibility and mechanical stability under compression, preventing particle destruction and core exposure.
Solution Approach 2:
The patent employs parameter changes by modifying the physical and chemical properties of the coating through the addition of polysorbate. This changes the coating's mechanical parameters (flexibility, elasticity, compression resistance) to optimize performance during tablet pressing while maintaining protective function.
2Strength
If Carnauba wax is used alone to coat particles, then the coating provides hardness and structural integrity, but it is too brittle for some applications and lacks sufficient flexibility
Solution Approach 1:
The patent uses polysorbate as an intermediary substance that mediates between the rigid Carnauba wax matrix and the mechanical stresses applied during compression. The polysorbate molecules intercalate within the wax structure, acting as a plasticizer that reduces brittleness and enhances flexibility without compromising the overall structural integrity provided by the Carnauba wax.
Data Source
AI summary
The present patent application relates to a novel coating system, wherein the coating comprises Carnauba wax and at least one polysorbate. Furthermore it relates to compositions coated with such a coating system and the use of such compositions in the production of tablets.