Carotenoid Isomer Composition Stability Bioavailability
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Solution Overview
Problem
Current carotenoid-based products, such as lycopene from tomato sources, exhibit low bioavailability due to their isomeric profiles, with the 13-Z isomer being particularly unstable and reducing overall stability and bioavailability, while existing solutions have not effectively enhanced bioavailability and stability simultaneously.
Innovation Solution
A composition enriched in 5-Z and 9-Z lycopene isomers with a low content of 13-Z isomers, achieved through isomerization using solid catalysts or prolonged heating, to create a stable and bioavailable form of carotenoids, which can be incorporated into foodstuffs, supplements, cosmetics, or pharmaceuticals.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If thermal processing is used to increase Z-isomers, then bioavailability is improved, but stability deteriorates due to retro-isomerization
Solution Approach 1:
The patent changes the isomeric profile parameters by enriching the composition in stable Z-isomers (5-Z and 9-Z) while minimizing unstable 13-Z isomers. This selective parameter modification allows achieving high bioavailability through Z-isomer enrichment while maintaining stability by avoiding the unstable 13-Z configuration, thus resolving the contradiction between improved bioavailability and maintained stability.
Solution Approach 2:
The patent applies local quality by differentiating between various Z-isomers and treating them differently. Specifically, it enriches in the stable Z-isomers (5-Z and 9-Z) while minimizing the unstable 13-Z isomer. This selective approach allows the composition to benefit from Z-isomer bioavailability enhancement without suffering from the instability of particular Z-isomers.
2Reliability
If 13-Z isomer content is increased, then bioavailability is enhanced, but stability deteriorates due to retro-isomerization
Solution Approach 1:
The patent modifies the isomeric composition parameters by specifically limiting the 13-Z isomer content to less than 10% while enriching other Z-isomers. This parameter control strategy achieves the bioavailability benefits of Z-isomers without incorporating the unstable 13-Z isomer that would cause retro-isomerization and stability issues.
Solution Approach 2:
The patent converts the potential harm of Z-isomer instability into benefit by selectively enriching only the stable Z-isomers (5-Z and 9-Z). The knowledge of which Z-isomers are unstable (13-Z) is used to avoid incorporating them, while the stable Z-isomers are enriched to provide bioavailability enhancement without the associated stability problems.
3Stability of the object's composition
If all-E configuration is maintained, then stability is preserved, but bioavailability remains low
Solution Approach 1:
The patent changes the isomeric configuration parameter from predominantly all-E to a mixture enriched in Z-isomers (5-Z and 9-Z) while minimizing 13-Z. This parameter change improves bioavailability through Z-isomer enrichment while maintaining stability by avoiding the unstable 13-Z configuration, thus resolving the contradiction between stability and bioavailability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting composition demonstrates improved stability and bioavailability, with the 5-Z and 9-Z isomers enhancing bioefficacy and maintaining stability under storage conditions, while minimizing retro-isomerization, thereby providing a more effective nutritional and health benefits.
Implementation Method 1
isomerization using solid catalysts
Implementation Method 2
Thermal isomerization of lycopene is known to improve its bioavailability from food matrices
Data Source
Figure 1
AI summary
Compositions that provide health benefits and methods regarding same are presented. In an embodiment, the present invention provides a primary composition comprising at least one carotenoid-containing material, enriched in Z isomers of the carotenoid compound. For example, the carotenoid-containing material contains by weight a greater percentage of an isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof than of 13-Z isomer.