Carotenoid Particles Agar Gel Cyclodextrin Exudation
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Solution Overview
Problem
Carotenoid-containing particles produced without gelatin as a hydrophilic polymer gelator often experience exudation during tableting and storage, leading to reduced carotenoid content and potential allergic reactions due to animal-derived materials.
Innovation Solution
The use of agar as a hydrophilic polymer gelator combined with cyclodextrin and/or plant proteins in the continuous phase effectively prevents carotenoid exudation by forming stable particles, even at higher carotenoid concentrations, eliminating the need for animal-derived materials.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If gelatin is used as a hydrophilic polymer gelator to produce carotenoid-containing particles, then the particles have high strength and excellent barrier performance preventing carotenoid exudation, but there is a risk of inducing allergy due to animal protein content
Solution Approach 1:
The invention changes the chemical composition parameters by substituting gelatin with agar (a plant-derived polysaccharide), thereby eliminating animal protein while maintaining the gel structure's ability to prevent carotenoid exudation through controlled gelation properties
Solution Approach 2:
The invention replaces the problematic gelatin material with agar, which serves the same functional purpose (forming protective gel matrix) but without the harmful allergic properties, effectively discarding the harmful component while retaining the useful function
2Object-affected harmful factors
If hydrophilic polymer gelators other than gelatin (agar, carrageenan, alginic acid) are used to substitute gelatin, then the allergy risk is reduced, but carotenoid may exude from particles due to pressure during tableting or external factors
Solution Approach 1:
The invention creates a composite gel system by combining agar with cyclodextrin and/or plant protein, where the cyclodextrin forms inclusion complexes with carotenoid molecules and the plant protein provides structural reinforcement, together achieving superior carotenoid retention compared to agar alone
Solution Approach 2:
The invention employs a nested structure where cyclodextrin molecules form host-guest inclusion complexes with carotenoid molecules, and this complex is further embedded within the agar gel matrix and plant protein network, creating multiple containment levels that prevent carotenoid exudation
3Reliability
If carotenoid content in particles is reduced to prevent exudation, then carotenoid exudation is prevented, but a large amount of particles must be taken to obtain the efficacy of carotenoid
Solution Approach 1:
The invention performs preliminary stabilization by forming inclusion complexes between cyclodextrin and carotenoid before particle formation, and by establishing a robust gel matrix structure with agar and plant protein that pre-prevents exudation pathways, allowing high carotenoid content to be maintained without subsequent loss
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method significantly reduces carotenoid exudation during tableting and storage, allowing for higher carotenoid content in particles while minimizing the risk of allergic reactions from animal-derived components.
Implementation Method 1
using agar as a hydrophilic polymer gelator to constitute the continuous phase
Implementation Method 2
adding a cyclodextrin and/or a plant protein to the agar
Data Source
AI summary
Provided are carotenoid-containing particles having, for preventing exudation of carotenoid at the time of tableting and during storage, a structure in which a carotenoid is dispersed in an agar gel containing a cyclodextrin and/or a plant protein.