Gas Chromatograph Carrier Gas Reduction via Dynamic Split Flow Control

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Solution Overview

Problem

Traditional gas chromatography systems consume large volumes of carrier gas, particularly helium, due to high split and septum purge flows, leading to contamination and elevated baselines, and existing methods to reduce consumption either result in undesirable effects or require additional hardware and maintenance.

Innovation Solution

A system and method that utilize a common gas source for both carrier and inlet gas flows, with controlled flow rates to minimize carrier gas consumption by using a valve and calibrated restrictors to deliver two levels of carrier gas flow, and a T-connector to interpose the injector and analytical column, allowing for reduced inlet gas flow during injection and increased flow during separation to prevent contamination.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If large split flow is used to reduce contaminants, then baseline stability is improved, but carrier gas consumption increases

Engineering Contradiction:
Improvebaseline stabilityVSAvoidcarrier gas consumption
Core Design Contradiction:
ReliabilityVSLoss of substance

Solution Approach 1:

The system implements periodic switching between high split flow mode (during/after injection) to flush contaminants and low split flow mode (during separation) to conserve carrier gas. The controller automatically adjusts the split flow rate based on the operational phase, achieving both baseline stability and gas conservation throughout the analytical cycle.

Inventive Principle:
Principle #19Periodic action

Solution Approach 2:

The split flow rate is made dynamic rather than static, allowing the system to adapt the carrier gas flow to different operational requirements. The controller modulates the split flow between high and low values based on real-time needs, optimizing both contaminant removal and gas consumption during different phases of the chromatographic run.

Inventive Principle:
Principle #15Dynamics

2Loss of substance

If low split flow is used to conserve carrier gas, then carrier gas consumption is reduced, but baseline stability deteriorates

Engineering Contradiction:
Improvecarrier gas consumptionVSAvoidbaseline stability
Core Design Contradiction:
Loss of substanceVSReliability

Solution Approach 1:

The system implements periodic switching between high split flow mode (during/after injection) to flush contaminants and low split flow mode (during separation) to conserve carrier gas. The controller automatically adjusts the split flow rate based on the operational phase, achieving both baseline stability and gas conservation throughout the analytical cycle.

Inventive Principle:
Principle #19Periodic action

Solution Approach 2:

The split flow rate is made dynamic rather than static, allowing the system to adapt the carrier gas flow to different operational requirements. The controller modulates the split flow between high and low values based on real-time needs, optimizing both contaminant removal and gas consumption during different phases of the chromatographic run.

Inventive Principle:
Principle #15Dynamics

3Measurement precision

If high purity carrier gas is used for analytical column, then data quality is improved, but system complexity increases due to additional gas connections and valves

Engineering Contradiction:
Improvedata qualityVSAvoidnumber of gas connections and valves
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system merges the carrier gas supply for the analytical column with the inlet gas supply for the injector, using a single common high purity carrier gas source. The controller intelligently directs the carrier gas to either the column or the injector based on operational phase, eliminating the need for separate gas lines, additional valves, and complex gas management infrastructure.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The carrier gas system is designed to serve multiple functions: it acts as both the carrier gas for the analytical column and the inlet gas for the injector. This multi-functional approach reduces the number of gas connections and valves needed, simplifying the system while maintaining data quality through consistent use of high purity carrier gas.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Significantly reduces the consumption of high purity carrier gas while maintaining data quality by preventing contaminants from entering the analytical column, eliminating the need for auxiliary gases and associated hardware, and achieving comparable chromatographic performance to conventional systems.

Implementation Method 1

a valve and calibrated restrictors for delivering two levels of carrier gas flow to the conduit

Methodology Applied
Scientific EffectFlow restriction: Pressure Drop

Implementation Method 2

oxidation of the column stationary phase due to larger concentrations of oxygen which has back-diffused through the septum

Methodology Applied
Scientific EffectDiffusion: Diffusion

Data Source

PatentEP3889598B1Carrier gas reduction for gas chromatography
Publication Date: 2024.09.11 THERMO FINNIGAN LLC
  • EP3889598B1 patent drawingFigure 1
  • EP3889598B1 patent drawingFigure 2
  • EP3889598B1 patent drawingFigure 3

AI summary

A device for a gas chromatograph (GC) system includes an injector connected to an inlet gas line and a conduit assembly. The inlet gas line is configured to pressurize an input end of a column and to deliver a split or purge flow. The conduit assembly includes a conduit surrounding the input end of the analytical column and coupled to a carrier gas line and a controller. The inlet gas line and the carrier gas line connect to a common gas source. The controller, connected to the conduit, has a first mode delivering a flow of carrier gas which is less than the column flow during an injection period to effect a sample transfer to the column and a second mode delivering a flow of carrier gas greater than the column flow following an injection period to prevent the split or purge flow from entering the column.