Cartridge Protrusion Stabilizes Liquid Level for Detection Accuracy
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Solution Overview
Problem
Existing detection methods struggle to stabilize the liquid level of samples in mixing chambers, leading to instability and reduced accuracy in detecting target substances, particularly when magnetic particles are involved, as the liquid level affects the collection and fluorescence detection processes.
Innovation Solution
A cartridge design with a chamber configuration featuring a first region away from the rotating shaft and a protrusion that stabilizes the liquid level, including a curved surface to prevent sample loss and ensure uniform accommodation, connected to a flow path to manage sample movement and prevent leakage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the cartridge is rotated to mix the sample, then the mixing efficiency is improved, but the liquid level becomes unstable after stopping rotation
Solution Approach 1:
The chamber is divided into a first region for sample storage and a second region closer to the rotating shaft, with a protrusion structure separating them. This segmentation allows the sample to be confined to the first region while allowing rotation for mixing, and then stabilizing in the predetermined state after rotation stops.
Solution Approach 2:
The protrusion structure is pre-configured in the chamber to create a boundary that guides the liquid level to a predetermined stable state after rotation. This preliminary structural arrangement ensures that when rotation stops, the liquid naturally settles into the desired configuration without additional control mechanisms.
2Reliability
If the liquid level is not stabilized after mixing, then the sample may spill out or detection accuracy reduces, but adding stabilization structures increases device complexity
Solution Approach 1:
The chamber is divided into a first region for sample storage and a second region closer to the rotating shaft, with a protrusion structure separating them. This segmentation allows the sample to be confined to the first region while allowing rotation for mixing, and then stabilizing in the predetermined state after rotation stops.
Solution Approach 2:
The protrusion structure is pre-configured in the chamber to create a boundary that guides the liquid level to a predetermined stable state after rotation. This preliminary structural arrangement ensures that when rotation stops, the liquid naturally settles into the desired configuration without additional control mechanisms.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cartridge effectively stabilizes the liquid level, ensuring accurate detection of target substances by maintaining the sample in a predetermined position, enhancing the collection of magnetic particles and fluorescence detection accuracy.
Implementation Method 1
a cartridge (20) rotated about a rotating shaft (42) for detecting a target substance
Data Source
AI summary
The present invention provides a cartridge, a detection method, and a detection device capable of stabilizing the liquid level of a sample accommodated in a chamber in a predetermined state. A cartridge 20, that is rotated around a rotating shaft 42 for detecting a target substance, is provided with a chamber 100 in which a sample containing a target substance is stored. The chamber 100 includes a first region 110 in which a sample is stored, a second region 120 disposed at a position closer to the rotating shaft 42 than the first region 110, and a protrusion 130 protruding from a position between the first region 110 and the second region 120 to the inner side of the chamber 100.