CASM Temporal-Interaction Scoring for Individualized Drug Dosing

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Solution Overview

Problem

Conventional mathematical and statistical methods are inadequate for quantifying how complex adaptive systems, such as living beings, function in the time dimension, limiting progress in drug development and medicine by failing to provide precise and individualized drug dosing.

Innovation Solution

A complex adaptive systems metrology (CASM) platform that processes multivariate time series data to compute universally standardized temporal-interaction scores, accounting for temporal interactions and adaptivity, enabling precise drug targeting and treatment evaluation for individual patients.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional mathematical and statistical methods are used, then measurement and analysis can be performed, but they are inadequate for quantifying how complex adaptive systems function in the time dimension

Engineering Contradiction:

Improveprecision of quantifying complex adaptive system functionVSAvoidability to handle temporal interactions in complex adaptive systems

Core Design Contradiction:

Measurement precisionVSAdaptability or versatility

Solution Approach 1:

The patent introduces new computational parameters including temporal-interaction scores, adaptivity indices, and complexity metrics that transform conventional static measurements into dynamic temporal assessments. These parameter changes enable precise quantification of how complex adaptive systems function over time while maintaining adaptability to individual system characteristics.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs computational algorithms as intermediaries that bridge conventional mathematical methods and complex adaptive system analysis. These algorithms process multivariate time series data to extract temporal interaction patterns, enabling precise measurement of system function without requiring fundamental changes to underlying mathematical frameworks.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Measurement precision

If physical science methods are used, then targeting can be achieved for physical entities, but they are less successful for targeting drugs to individuals

Engineering Contradiction:

Improveprecision of drug targeting to individualVSAvoidcomplexity of individualized treatment system

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The patent segments the complex task of individualized drug targeting into distinct computational components: data acquisition from multivariate time series, temporal-interaction score calculation, adaptivity index computation, and treatment recommendation generation. This segmentation manages system complexity while achieving precise individualized targeting through systematic processing of each component.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent transforms conventional treatment parameters into individualized parameters by computing temporal-interaction scores and adaptivity indices specific to each patient's multivariate time series data. This parameter transformation enables precise drug targeting to individuals while managing complexity through standardized computational procedures.

Inventive Principle:

Principle #35Parameter changes

3Adaptability or versatility

If conventional methods are used, then general treatment protocols can be established, but they fail to provide precise and individualized drug dosing

Engineering Contradiction:

Improveindividualization of drug dosingVSAvoidefficiency of drug development and medicine

Core Design Contradiction:

Adaptability or versatilityVSProductivity

Solution Approach 1:

The patent enables self-service individualization where each patient's multivariate time series data automatically generates their own temporal-interaction scores and adaptivity indices without requiring manual customization. This self-service approach achieves precise individualized dosing while maintaining productivity through automated computational processes that scale efficiently.

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent changes dosing parameters from fixed conventional values to dynamic individualized parameters derived from each patient's temporal-interaction scores. This parameter change enables precise individualized dosing while improving productivity through automated calculation of personalized parameters from routine clinical data.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS12469609B2Targeting individuals with optimal safe and effective doses by applying complex adaptive systems metrology to functional brain imaging data and other action variable data

Publication Date: 2025.11.11 BAGNE CURTIS A

AI summary

Methods and systems are described for a computer-implemented complex adaptive systems metrology (CASM) technique for generating universally and mathematically standardized scores that quantify longitudinal evidence for either temporal-interaction scores or temporal-interaction benefit-and-harm scores to determine a quantitative significance estimate of scores for either standardized temporal-interaction scores or the standardized temporal-interaction benefit-and-harm scores.