Catechol-Modified Chitosan Dressing for Durable Tissue Hemostasis

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current chitosan materials fail to maintain integrity and adhere to tissues in harsh biological environments such as the stomach and vascular systems, limiting their application in rapid bleeding control and wound healing, particularly in minimally invasive surgeries and gastrointestinal bleeding.

Innovation Solution

Development of catechol modified chitosan materials that resist dissolution and adhere to tissues, allowing for rapid bleeding control and wound healing by forming a local clot and promoting tissue healing, suitable for minimally invasive procedures.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If standard chitosan materials are used in harsh biological environments, then they provide basic hemostatic function, but they rapidly dissolve and lose adhesion within hours

Engineering Contradiction:

Improveadhesion stabilityVSAvoidintegrity duration

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent combines chitosan with catechol functional groups to create a composite material that integrates the hemostatic properties of chitosan with the adhesion and dissolution resistance properties of catechol, achieving both strong tissue adhesion and prolonged integrity in harsh biological environments

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent modifies the chemical parameters of chitosan by introducing catechol groups, which fundamentally changes the material's interaction with biological fluids and tissues, enabling resistance to dissolution and enhanced adhesion stability in the gastrointestinal tract and vascular systems

Inventive Principle:

Principle #35Parameter changes

2Speed

If chitosan materials are designed for rapid adhesion to tissue, then they achieve quick hemostasis, but they dissolve too quickly to maintain function

Engineering Contradiction:

Improveadhesion speedVSAvoidadhesion duration

Core Design Contradiction:

SpeedVSDuration of action of stationary object

Solution Approach 1:

The catechol-chitosan composite enables rapid adhesion through catechol's quick binding to tissue while simultaneously providing prolonged adhesion duration through the material's resistance to dissolution in biological fluids, achieving both speed and sustainability of adhesion

Inventive Principle:

Principle #40Composite materials

3Reliability

If chitosan is used to control bleeding in gastrointestinal tract, then it provides hemostatic effect, but it rapidly degrades in the harsh GI environment

Engineering Contradiction:

Improvehemostatic effectivenessVSAvoidmaterial stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent chemically modifies chitosan by incorporating catechol groups, which fundamentally changes the material's stability parameters, enabling it to resist degradation in the harsh gastrointestinal environment while maintaining its hemostatic effectiveness

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The catechol-chitosan composite material combines the hemostatic properties of chitosan with the environmental stability of catechol, creating a material that maintains both therapeutic effectiveness and compositional stability in the gastrointestinal tract

Inventive Principle:

Principle #40Composite materials

4Ease of operation

If minimally invasive procedures are performed, then patient morbidity and hospital cost are reduced, but control of bleeding becomes highly challenging

Engineering Contradiction:

Improvesurgical invasivenessVSAvoidbleeding control

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The catechol-chitosan composite provides reliable bleeding control in minimally invasive procedures by combining rapid adhesion, strong hemostatic effect, and prolonged durability, enabling effective hemorrhage control without requiring open surgical intervention

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The material adheres automatically to tissue upon contact and activates its hemostatic function autonomously at the bleeding site, providing reliable bleeding control without requiring complex delivery systems or additional surgical manipulation

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The catechol modified chitosan materials provide effective and sustained adhesion to tissues, controlling bleeding and promoting healing in challenging environments, reducing morbidity and mortality associated with gastrointestinal and surgical bleeding.

Implementation Method 1

tissue adherent chitosan material

Methodology Applied

Scientific EffectAdhesion: Adhesive

Implementation Method 2

resist dissolution and rapid loss in harsh environments such as the stomach

Methodology Applied

Scientific EffectResist dissolution:

Implementation Method 3

promotion of local clot formation

Methodology Applied

Scientific EffectCoagulation: Coagulation

Data Source

PatentUS12616771B2Tissue adherent chitosan material that resists dissolution

Publication Date: 2026.05.05 TRICOL BIOMEDICAL INC

AI summary

The present invention relates to a biocompatible, foldable, thin profile, low mass and high surface area, chitosan dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g., gastrointestinal tract, bladder (in particular in connection with the TURP procedure). The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided.