Catechol-Modified Chitosan Dressing for GI Bleeding

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Solution Overview

Problem

Current methods for controlling gastrointestinal bleeding, particularly in the upper gastrointestinal tract, are inadequate due to challenges in delivery, adhesion, enzyme activity, and acidity, leading to high morbidity and mortality rates and significant healthcare costs.

Innovation Solution

A chitosan-based gastrointestinal hemostatic dressing modified with catechol, which is thin, foldable, and capable of rapid adherence to gastric mucosa, effectively controlling bleeding rates from 1 to 200 ml/min, resisting dissolution in acidic and enzymatic environments for up to 12 hours, and promoting hemostasis without the need for invasive procedures.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional endoscopic methods (thermal therapy, injection, clips) are used for GI bleeding control, then hemostasis can be achieved in many cases, but delivery is difficult in active pulsating bleeding conditions and visibility of lesions is poor

Engineering Contradiction:

Improvehemostasis achievementVSAvoiddelivery difficulty

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The chitosan dressing acts as an intermediary substance that is delivered through the endoscope and adheres to the bleeding lesion. The dressing comprises chitosan particles that accumulate at the bleeding site, providing a hemostatic barrier without requiring direct manipulation of the bleeding vessel, thus solving the delivery visibility problem.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The chitosan dressing is designed to self-adhere to the bleeding lesion through its inherent adhesive properties and to self-activate hemostasis through contact with blood. The dressing automatically accumulates at the bleeding site without requiring additional endoscopic manipulation, achieving hemostasis through its own properties.

Inventive Principle:

Principle #25Self-service

2Ease of operation

If chitosan dressing is made thin and foldable for better delivery through endoscopic channels, then deliverability improves, but adhesion strength to gastric mucosa may be compromised

Engineering Contradiction:

ImprovedeliverabilityVSAvoidadhesion strength

Core Design Contradiction:

Ease of operationVSStrength

Solution Approach 1:

The chitosan dressing is formulated as a thin, flexible film that can be folded and delivered through endoscopic channels. The thin film structure maintains sufficient mechanical strength and adhesion properties through the use of cross-linked chitosan networks and appropriate particle size distribution, resolving the contradiction between thinness and adhesion strength.

Inventive Principle:

Principle #30Flexible shells and thin films

Solution Approach 2:

The chitosan dressing is a composite material comprising cross-linked chitosan particles, chitosan polymers, and potential adjuvants. This composite structure provides both the thinness needed for delivery and the adhesion strength required for effective hemostasis, with the cross-linked network reinforcing the thin film structure.

Inventive Principle:

Principle #40Composite materials

3Duration of action of moving object

If chitosan dressing is designed to resist dissolution in acidic and enzymatic environments for prolonged hemostasis, then duration of action improves, but material stability in harsh gastric conditions becomes more challenging

Engineering Contradiction:

Improvehemostasis durationVSAvoidmaterial stability

Core Design Contradiction:

Duration of action of moving objectVSReliability

Solution Approach 1:

The chitosan dressing parameters are modified through cross-linking to alter its chemical and physical properties. The cross-linked structure increases resistance to acidic and enzymatic degradation, extending the duration of hemostatic action while maintaining material stability in the harsh gastric environment through controlled degradation kinetics.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The chitosan particles are pre-cross-linked during manufacturing to enhance their stability before deployment. This preliminary chemical modification ensures that the dressing maintains its structural integrity and hemostatic activity in the harsh gastric environment, extending its duration of action without compromising material stability.

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The catechol-modified chitosan dressing provides rapid and effective hemostasis in the gastrointestinal tract, reducing morbidity and mortality associated with gastrointestinal bleeding, while being deliverable through standard endoscopic channels and resistant to degradation in harsh gastric conditions.

Implementation Method 1

capable of rapid adherence to gastric mucosa

Methodology Applied

Scientific EffectAdhesion: Adhesive

Implementation Method 2

resisting dissolution in acidic and enzymatic environments for up to 12 hours

Methodology Applied

Scientific EffectAcid resistance:

Implementation Method 3

catechol modified chitosan

Methodology Applied

Scientific EffectOxidation: Oxidation

Data Source

PatentUS20210052766A1Chitosan dressing for control of gastrointestinal bleeding

Publication Date: 2021.02.25 TRICOL BIOMEDICAL INC

AI summary

The present invention relates to a biocompatible, foldable, thin profile, low mass and high surface area, chitosan dressing, optionally modified with catechol, and suitable for treating bleeding in a physiological environment, e.g. gastrointestinal tract. The characteristics and structures of the chitosan dressing are provided. Methods of making and using the chitosan dressing are also provided.