Catechol-Modified Tissue Adhesive via Dual Cross-Linking
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current biological tissue adhesives are inadequate for large-area in vivo applications, such as seroma prevention, due to issues like toxicity, short-term effectiveness, and instability in physiological environments, with existing adhesives like fibrin glue and cyanoacrylate-based products posing risks of infection and chronic toxicity.
Innovation Solution
A double-crosslinked biological tissue adhesive composition using catechol-grafted macromolecules cross-linked by multivalent metal ions and covalent bonding with genipin, providing rapid initial stability and long-term effectiveness, avoiding toxic components like aldehydes and cyan groups.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If fibrin glue is used for tissue adhesion, then biocompatibility is improved, but reliability deteriorates due to risk of blood-borne disease transmission and fast degradation
Solution Approach 1:
The invention extracts and eliminates the harmful components (blood-derived fibrinogen and thrombin) from the adhesive system while retaining the desirable biocompatibility. The adhesive uses synthetic or plant-based alternatives that do not carry blood-borne disease risks, thus resolving the contradiction between biocompatibility and infection risk.
Solution Approach 2:
The invention changes the chemical composition parameters of the adhesive from blood-derived proteins to alternative biocompatible materials. This parameter change maintains the beneficial biocompatibility while eliminating the associated infection risks and degradation issues inherent in fibrin-based adhesives.
2Strength
If cyanoacrylate-based adhesives are used, then adhesion strength is improved, but object-generated harmful factors worsen due to acute and chronic toxicity
Solution Approach 1:
The invention converts the typically harmful cyanoacrylate chemistry into a beneficial system by using modified cyanoacrylate monomers that polymerize to form non-toxic products. The adhesive maintains strong adhesion while eliminating the acute and chronic toxicity associated with conventional cyanoacrylate adhesives, thus converting a harmful material into a beneficial one.
Solution Approach 2:
The invention creates a composite adhesive system that combines cyanoacrylate-based polymers with biocompatible additives and modifiers. This composite approach maintains the strong adhesion properties of cyanoacrylate while incorporating components that reduce or eliminate toxicity, resolving the contradiction between strength and harmful factors.
3Strength
If glutaraldehyde-based adhesives are used, then adhesion strength is improved, but object-generated harmful factors worsen due to chronic toxicity
Solution Approach 1:
The invention extracts and removes glutaraldehyde from the adhesive formulation, eliminating the source of chronic toxicity. Alternative crosslinking agents or adhesion mechanisms are employed that maintain strong tissue bonding without the carcinogenic and toxic effects associated with glutaraldehyde-based adhesives.
Solution Approach 2:
The invention changes the chemical composition by replacing glutaraldehyde with non-toxic alternative crosslinking agents. This parameter change maintains the adhesion strength provided by crosslinking while eliminating the chronic toxicity and cancer risk associated with glutaraldehyde exposure.
4Area of stationary object
If conventional tissue adhesives are used for large-area applications, then coverage area is improved, but reliability deteriorates due to insufficient effectiveness in physiologically wet environments
Solution Approach 1:
The invention develops a composite adhesive system that combines hydrophobic and hydrophilic components. This composite structure enables the adhesive to maintain stability and adhesion strength in physiologically wet environments while being suitable for large-area applications, resolving the contradiction between application area and environmental stability.
Solution Approach 2:
The invention modifies the physical and chemical parameters of the adhesive to enhance its performance in wet environments. This includes adjusting the polymer composition, crosslinking density, and hydrophobicity/hydrophilicity balance to maintain adhesion strength and structural integrity when applied over large areas in physiological conditions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive exhibits high adhesive force, cytocompatibility, and stability in physiological conditions, suitable for seroma prevention and various medical applications, with a cost-effective and easy-to-use formulation.
Implementation Method 1
cross-linked by (a) complex formation between the at least one catechol moiety and the multivalent metal ion
Implementation Method 2
covalent bonding of the at least one cross-linkable functional group with the second cross-linker
Data Source
AI summary
A biological tissue adhesive composition is provided. The biological tissue adhesive composition comprises one or more macromolecules grafted with at least one catechol moiety and comprising at least one cross-linkable functional group, a first cross-linker for cross-linking the at least one catechol moiety, wherein the first cross-linker comprises or consists or a multivalent metal ion, and a second cross-linker for covalently cross-linking the at least one cross-linkable functional group, wherein the one or more macromolecules are cross-linked by (a) complex formation between the at least one catechol moiety and the multivalent metal ion, and (b) covalent bonding of the at least one cross-linkable functional group with the second cross-linker. Fabrication method and working principle of a biological tissue adhesive composition are also provided.