Catheter Manifold Bypass Conduit for Microsphere Dose Delivery

Solution Overview

Problem

Current cancer therapy delivery systems face issues with microsphere retention in the connection manifold of fluid delivery catheters due to step-changes in inner diameter, leading to inefficient delivery and accumulation of therapeutic agents, particularly in scenarios where dosages are small.

Innovation Solution

A catheter connection manifold bypass device with a fluid passage conduit and deformable tip that fits within the connection manifold, reducing step-changes in inner diameter and preventing microsphere accumulation by providing a streamlined flow path.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If a connection manifold with a cavity is used to connect fluid delivery catheters, then the manifold provides a connection interface for multiple catheters, but step-changes in inner diameter cause microsphere retention and accumulation

Engineering Contradiction:

Improveconnection interfaceVSAvoidmicrosphere retention

Core Design Contradiction:

Adaptability or versatilityVSObject-generated harmful factors

Solution Approach 1:

The bypass device extracts the fluid passage from the problematic manifold cavity environment. By routing fluid through a separate conduit that bypasses the manifold cavity, the device eliminates the step-change in inner diameter that causes microsphere retention, while still allowing the manifold to serve its connection function.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The bypass device acts as an intermediary between the manifold and the fluid delivery catheter. It provides a transition pathway that connects the manifold outlet to the catheter inlet while maintaining a consistent inner diameter, thereby mediating the connection without allowing microsphere accumulation.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Productivity

If microsphere suspension is delivered through a catheter connection manifold, then therapy can be delivered to patients, but microspheres accumulate in the manifold cavity leading to incomplete dose delivery

Engineering Contradiction:

Improvetherapy deliveryVSAvoidmicrosphere loss

Core Design Contradiction:

ProductivityVSLoss of substance

Solution Approach 1:

The bypass device extracts the fluid passage from the problematic manifold cavity environment. By routing fluid through a separate conduit that bypasses the manifold cavity, the device eliminates the step-change in inner diameter that causes microsphere retention, while still allowing the manifold to serve its connection function.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The bypass device ensures continuous, uninterrupted flow of microsphere suspension from the manifold to the catheter. By providing a streamlined passage without step-changes in diameter, the device maintains continuous fluid flow that prevents microsphere accumulation and ensures complete delivery of the therapeutic dose.

Inventive Principle:

Principle #20Continuity of useful action

3Ease of operation

If standard catheter connection manifolds are used, then connection is simplified, but flushing time and volume increase due to microsphere accumulation

Engineering Contradiction:

Improveconnection simplicityVSAvoidflushing time

Core Design Contradiction:

Ease of operationVSLoss of time

Solution Approach 1:

The bypass device extracts the fluid passage from the problematic manifold cavity environment. By routing fluid through a separate conduit that bypasses the manifold cavity, the device eliminates the step-change in inner diameter that causes microsphere retention, while still allowing the manifold to serve its connection function.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The bypass device acts as an intermediary between the manifold and the fluid delivery catheter. It provides a transition pathway that connects the manifold outlet to the catheter inlet while maintaining a consistent inner diameter, thereby mediating the connection without allowing microsphere accumulation.

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS20250367424A1Catheter connection manifold bypass accessory device

Publication Date: 2025.12.04 BOSTON SCIENTIFIC SCIMED INC

AI summary

Embodiments herein relate to catheter connection manifold bypass devices, cancer therapy delivery systems, and related methods. For example, a catheter connection manifold bypass device can be included having a fluid passage conduit with a proximal end and a distal end. The bypass device can also include a deformable tip disposed around the distal end of the fluid passage conduit. The deformable tip can fit within a distal portion of a cavity within a connection manifold for a fluid delivery catheter. The bypass device can include a proximal connection port that can be connected to the proximal end of the fluid passage conduit. The bypass device can also include a connection adapter defining a channel, wherein the fluid passage conduit passes through the channel. The distal end of the connection adapter can be configured to attach to a proximal end of the fluid delivery catheter. Other embodiments are also included herein.