Catheter Dual Coating Reduces Embolic Adhesion
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Solution Overview
Problem
The adhesion of water-based liquid embolic solutions to coatings on catheters can lead to destabilization of the embolism and pose risks to patients during therapeutic embolization procedures.
Innovation Solution
A dual-coating system is applied to the catheter, where a first coating of a polymer containing D-glucuronic acid and N-acetyl-D-glucosamine monomers is covered by a second coating of ethyl cellulose, specifically at the distal portion of the catheter, to reduce attractive forces between the liquid embolic solutions and the catheter.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a coating is applied to the catheter, then the catheter surface is protected and lubricated, but liquid embolic solutions adhere to the coating causing embolism destabilization
Solution Approach 1:
The catheter coating is divided into two distinct segments: a first coating (hydrophilic polymer coating) that provides surface protection and lubrication, and a second coating (superhydrophobic coating) applied distally that prevents liquid embolic solution adhesion. This segmentation allows each coating to perform its specific function without interfering with the other.
Solution Approach 2:
The superhydrophobic second coating is applied only to the distal portion of the catheter where liquid embolic solutions are delivered, rather than the entire catheter length. This localized application ensures that the distal tip has non-adhesive properties while the proximal portion maintains the hydrophilic coating's protective and lubricating functions.
2Ease of manufacture
If a single coating is applied to the catheter, then the manufacturing process is simple, but the catheter cannot simultaneously provide protection and prevent liquid adhesion
Solution Approach 1:
The catheter employs a composite coating structure consisting of a hydrophilic polymer coating layer and a superhydrophobic coating layer. This composite structure combines the beneficial properties of both materials: the hydrophilic coating provides protection and lubrication, while the superhydrophobic coating prevents liquid embolic solution adhesion, achieving dual functionality through material composition.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The dual-coating system effectively reduces the adhesion of liquid embolic solutions to the catheter, stabilizing the embolism and enhancing patient safety during medical procedures.
Implementation Method 1
the adhesion of water-based liquid embolic solutions on coatings commonly found on catheters... reduce attractive forces between the liquid embolic solutions and the catheter
Data Source
AI summary
A catheter that includes a proximal portion, a distal portion, and an interior lumen therebetween is provided. The distal portion has a distal exterior catheter surface having a coated section that includes a first coating and a second coating. The first coating includes a polymer that includes a D-glucuronic acid monomer and an N-acetyl-D-glucosamine monomer. The second coating includes an ethyl cellulose polymer atop the first coating, and bound to at least a portion of the first coating. The surface area of the first coating is greater than the surface area of the second coating. The second coating masks liquid embolic solutions from the first coating, which helps reduce attractive forces between the liquid embolic solutions and the catheter.