Insertable Catheter Patch with UV Adhesive
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Solution Overview
Problem
Current therapies for closing ventricular septal defects are invasive and can cause tissue damage due to mechanical anchoring, and existing catheter-based interventions face challenges in delivering and securing devices within the beating heart.
Innovation Solution
An insertable catheter device with an expandable balloon and a fluid conduit for inflating and retracting a patch, which uses a UV-activated biodegradable adhesive for attachment to the heart tissue without mechanical anchoring, allowing for minimally invasive access and deployment of a biocompatible, elastomeric patch.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If surgical techniques are used for VSD closure, then reliable defect closure is achieved, but invasive procedures and tissue damage occur
Solution Approach 1:
The patent replaces mechanical anchoring systems with photopolymerization-based chemical bonding. The adhesive layer with photopolymerizable functional groups is cured by light irradiation through the transparent patch, creating strong chemical bonds between the patch and heart tissue without mechanical penetration or anchoring, thus eliminating tissue damage while maintaining reliable closure
Solution Approach 2:
The patent introduces an adhesive layer as an intermediary between the patch and heart tissue. This adhesive layer contains photopolymerizable functional groups that form chemical bonds when exposed to light, serving as a mediator that securely attaches the patch to the tissue without requiring direct mechanical contact or anchoring, thereby achieving reliable closure without tissue damage
2Ease of operation
If catheter-based devices with mechanical anchoring are used, then minimally invasive access is achieved, but tissue damage and device fragility occur
Solution Approach 1:
The patent replaces mechanical anchoring mechanisms with photopolymerization-based chemical bonding. The adhesive layer is cured by light irradiation to create strong chemical bonds between the patch and heart tissue, eliminating the need for mechanical anchoring devices that cause tissue damage, while maintaining the minimally invasive catheter-based delivery approach
Solution Approach 2:
The patent changes the bonding mechanism from mechanical to chemical by using photopolymerizable functional groups in the adhesive layer. When exposed to light of appropriate wavelength, these functional groups undergo polymerization to form strong chemical bonds, providing secure attachment without mechanical forces that could damage delicate heart tissue
3Strength
If permanent non-biodegradable materials are used for patch closure, then long-term structural support is achieved, but foreign body response and complications occur
Solution Approach 1:
The patent changes the material property from permanent to biodegradable by using a biodegradable patch and adhesive system. The patch and adhesive are designed to maintain structural integrity and provide strong support during the critical healing period, then gradually degrade over time, eliminating foreign body response while ensuring long-term structural support when needed
Solution Approach 2:
The patent employs biodegradable materials that perform their structural support function temporarily during the healing process, then naturally degrade and are absorbed by the body. This allows the patch to provide necessary structural support when needed, then be discarded by the body's natural processes, eliminating long-term foreign body response and complications
4Object-affected harmful factors
If elastic biodegradable adhesive is used instead of mechanical anchoring, then no tissue erosion occurs, but adhesive application precision must be maintained
Solution Approach 1:
The patent applies the adhesive layer to the patch surface before implantation, allowing precise control of adhesive placement during manufacturing. The photopolymerizable functional groups are pre-positioned on the patch, ensuring accurate adhesive application and eliminating the need for precise mechanical anchoring during the minimally invasive procedure, while preventing tissue erosion through controlled chemical bonding
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device achieves effective patch-to-tissue adhesion without mechanical anchoring, reduces tissue damage, and allows for the use of a biodegradable adhesive that matches the heart's elasticity, enabling secure closure of defects with minimal invasive procedures and no long-term complications.
Implementation Method 1
uses a UV-activated biodegradable adhesive for attachment to the heart tissue
Data Source
AI summary
An insertable catheter device includes a shaft including a proximal end and a distal end, an expandable balloon, and an actuator configured to expand and retract the expandable balloon. The actuator includes a fluid conduit that extends through the shaft and is coupled with the expandable balloon to enable inflation and retraction of the expandable balloon via injection or withdrawal of a fluid to or from the expandable balloon via the fluid conduit. The expandable balloon is displaceably retractable into the shaft and extendable from the shaft. A fluid pump is coupled with the fluid conduit to pump the fluid through the fluid conduit. A patch is positioned to be displaced by the expandable balloon when the expandable balloon is inflated, and the expandable balloon is displaceably retractable into the shaft and displaceably extendable from the shaft.