Catheter Tip Laser Irradiation for Precise Intraluminal Targeting
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Solution Overview
Problem
Existing light irradiation devices face challenges in efficiently and accurately delivering light to specific positions within a biological lumen, particularly due to issues with optical transmission members causing light leakage, attenuation, and wavelength changes, as well as the difficulty in selectively targeting cancer cells using NIR-PIT.
Innovation Solution
A light irradiation device with a laser light source at its tip, emitting laser light in a predetermined wavelength range and direction, intersecting the longitudinal axis, and a catheter with a light transmission portion, allowing direct emission of laser light without optical fibers, and optionally incorporating markers for precise positioning.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Length of moving object
If optical transmission members (optical fibers) are used to deliver light to the target position, then light can be transmitted over distance, but light leakage, attenuation, and wavelength changes occur
Solution Approach 1:
The patent removes the optical transmission member (optical fiber) from the light delivery system. Instead of transmitting light through an optical fiber from a distant source, the light source is positioned directly at the tip of the catheter, eliminating the optical fiber and its associated problems of light leakage, attenuation, and wavelength changes.
Solution Approach 2:
The catheter itself becomes the intermediary structure that positions the light source directly at the target location. The light source is integrated into the catheter tip, serving as both the delivery vehicle and the emission point, eliminating the need for separate optical transmission components.
2Area of stationary object
If light is emitted in multiple directions to cover a wider area, then broader tissue coverage is achieved, but light intensity at specific target points decreases
Solution Approach 1:
The light emitting diodes are arranged to emit light in multiple directions (upward, downward, and laterally) simultaneously, creating a dynamic illumination pattern that adapts to the target tissue geometry. This multi-directional emission allows the system to maintain high intensity at the target while covering a broader area.
Solution Approach 2:
Different regions of the light emitting assembly have different emission characteristics. The light sources are positioned and oriented to create localized high-intensity zones at the target tissue while also providing broader coverage through lateral emission, with each region optimized for its specific function.
3Length of stationary object
If the light source is positioned deeper inside the body to treat deep cancer, then treatment of deep tumors is enabled, but positioning accuracy and targeting precision become more difficult
Solution Approach 1:
The patent replaces mechanical positioning systems with magnetic navigation technology. The catheter incorporates magnetic members that respond to external magnetic fields, enabling precise positioning and navigation to deep target locations through magnetic force control rather than mechanical manipulation.
Solution Approach 2:
Magnetic fields serve as an intermediary for positioning the catheter at deep target locations. The magnetic members in the catheter respond to externally applied magnetic fields, enabling non-contact, precise positioning and orientation at the target site without requiring complex mechanical steering mechanisms.
4Object-affected harmful factors
If NIR-PIT is used to selectively target cancer cells with antibodies, then side effects are reduced, but selective accumulation of the complex is not always sufficient for effective treatment
Solution Approach 1:
The light emitting diodes are positioned and oriented to emit light locally at the target tissue site, creating a localized treatment zone. This ensures that only the tissue at the catheter tip receives the activating light, providing spatial selectivity that complements the antibody-mediated selective accumulation of the photosensitive complex in cancer cells.
Solution Approach 2:
The system incorporates sensors to detect the presence and characteristics of target tissue, providing feedback that allows real-time adjustment of light emission parameters. This feedback mechanism ensures that light is activated only when the catheter is properly positioned at the target site, enhancing treatment precision and safety.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device enables efficient and accurate light delivery to targeted locations within the body, reducing side effects and improving therapeutic efficacy by minimizing light divergence and wavelength mismatches, while allowing for adjustable irradiation parameters and precise positioning.
Implementation Method 1
a laser light source that is disposed in a tip portion of the light irradiation device, and the laser light source is configured to emit laser light in a predetermined wavelength range
Implementation Method 2
A light transmission portion is formed in at least a portion of a side surface of a tip end of the catheter. The light transmission portion is configured to transmit the laser light emitted from the laser light source to exit the catheter.
Data Source
AI summary
A light irradiation has an elongated shape. The light irradiation device includes laser light sources that emit laser light in a predetermined wave range. The laser light sources emit laser light in a direction intersecting a longitudinal axial direction of the light irradiation device. The laser light sources of the light irradiation device locally transmit the laser light to a particular location of a living body.