Cationic Aromatic Copolymer Embolic Agent for Catheter Adhesion
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Solution Overview
Problem
Conventional liquid embolic materials like NBCA and EVOH can adhere to catheter tips, risking damage to blood vessel walls or catheter insertion sites during withdrawal, and EVOH requires DMSO as a solvent, which can cause neurotoxicity and local nerve damage.
Innovation Solution
A copolymer with an alternating arrangement of cationic functional group-containing monomer units and aromatic group-containing monomer units is used, which allows for easy injection with a syringe and forms a safe, stable blood clot-like gel mass through electrostatic interaction with blood components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional liquid embolic materials (NBCA, EVOH) are used, then vascular embolization effect is achieved, but the material adheres to catheter tip causing damage risk to blood vessel wall
Solution Approach 1:
The invention changes the chemical composition parameters of the embolic material by using a copolymer with specific cationic and aromatic group ratios, and by selecting water as solvent instead of traditional organic solvents, thereby reducing adhesion to catheter while maintaining embolization efficacy
Solution Approach 2:
The invention uses a composite copolymer structure combining cationic functional groups (for electrostatic interaction with blood) and aromatic groups (for hydrophobic interaction), creating a material that achieves embolization without excessive catheter adhesion
2Reliability
If EVOH is used as embolic material, then embolization is achieved, but DMSO solvent causes neurotoxicity and local nerve damage
Solution Approach 1:
The invention extracts and removes the harmful DMSO solvent from the embolic material formulation, replacing it with water as the solvent, thereby eliminating neurotoxicity while preserving the embolization function through the copolymer's electrostatic and hydrophobic interactions
Solution Approach 2:
The copolymer acts as an intermediary that enables embolization through electrostatic interaction with blood components, replacing the need for DMSO as a solvent mediator and thereby eliminating its toxic effects
3Reliability
If EVOH is used, then embolization is achieved, but multiple administrations are required increasing treatment time and cost
Solution Approach 1:
The invention optimizes the copolymer's molecular weight, charge density, and hydrophobicity parameters to achieve complete embolization in a single administration, eliminating the need for repeated treatments required by EVOH
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The copolymer provides vascular embolization properties comparable to conventional agents while ensuring safety and stability in the body, with improved injectability and reduced risk of catheter-related complications.
Implementation Method 1
administration of the copolymer into a blood vessel forms a safe and stable blood clot-like gel mass through electrostatic interaction with blood components
Data Source
AI summary
The embolic agent according to the present invention includes as an active ingredient a copolymer of a cationic functional group-containing monomer and an aromatic group-containing monomer, the copolymer having at least a part thereof a structure represented by general formula (I) (in the formula, R11 and R12 are hydrogen atoms or alkyl groups having 1 to 20 carbon atoms which may have a substituent, and satisfy a relational formula: R11=R12; Y11 and Y12 are each independently a single bond or an alkylene group having 1 to 20 carbon atoms; Ar11 is an aromatic hydrocarbon group having 6 to 16 carbon atoms which may have a substituent; X11 is an ammonium group or an amino group; and n11 is an integer of 10 to 1,000.)