Cationic Silicone Hydrogel Lens for Linear Anionic Release
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing contact lenses struggle with controlled release of comfort agents, often experiencing burst release or inadequate duration, which affects comfort and stability.
Innovation Solution
A silicone hydrogel contact lens with a polymeric lens body composed of specific monomer ratios, including 3-(dimethylamino)propyl methacrylate, facilitating controlled release of anionic agents for extended periods.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If comfort agents are introduced into contact lens materials, then comfort is improved, but burst release occurs instead of controlled release
Solution Approach 1:
The patent modifies the chemical parameters of the contact lens material by incorporating cationic groups (quaternary ammonium compounds or tertiary amines) into the silicone hydrogel matrix. This parameter change creates electrostatic interactions with anionic comfort agents, enabling controlled release over extended periods rather than burst release, while maintaining lens comfort and stability
2Stability of the object's composition
If comfort agents are trapped inside lens materials, then stability is improved, but release capability is limited
Solution Approach 1:
The patent creates a composite material system combining silicone hydrogel with cationic functional groups. This composite structure provides both the stability of the lens material and enhanced comfort agent release capability through electrostatic complexation, allowing the lens to maintain structural integrity while delivering higher quantities of comfort agents
3Reliability
If conventional silicone hydrogel contact lenses are used, then lens properties are maintained, but comfort agent uptake and release are insufficient
Solution Approach 1:
The patent changes the surface charge parameter of the silicone hydrogel lens by incorporating cationic groups, which enhances the lens's capacity to uptake and release anionic comfort agents through electrostatic interactions, while preserving the fundamental optical and mechanical properties of the lens
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The lens achieves a substantially linear release of anionic agents for at least 8 hours, with higher uptake and stability, avoiding burst release and maintaining lens properties.
Implementation Method 1
The 3-(dimethylamino)propyl methacrylate acyclic tertiary amine monomer advantageously facilitates uptake and/or sustained release of the at least one releasable anionic agent by the polymeric lens body
Data Source
Figure 1A~1B
AI summary
A cationic contact lens is described as well as methods of manufacturing the same. The cationic contact lens includes a polymeric lens body that is the reaction product of a polymerizable composition that includes at least one siloxane, at least one nonionic hydrophilic monomer and at least one acyclic tertiary amine monomer. The cationic contact lens can be an unworn sterile silicone hydrogel contact lens. The contact lens is capable of substantially linear release of a releasable anionic agent and the at least one acyclic tertiary amine monomer facilitates uptake and/or sustained release of the releasable anionic agent by the polymeric lens body. The contact lens can be present in a sealed contact lens package. The sealed contact lens package can include at least a) a base member having a cavity; b) a contact lens packaging solution in the cavity; c) a unworn sterile contact lens immersed in the contact lens packaging solution in the cavity with the releasable anionic agent present; and d) a cover that forms a liquid-tight seal with the base member.