Cationized Cellulose Hemostatic Dressing for Allergy-Free Wound Care
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Solution Overview
Problem
Chitosan-based hemostatic materials can cause shellfish allergies and are difficult to completely remove endotoxins, while existing wound dressings lack antibacterial and hemostatic properties, leading to potential infections and complications during wound healing.
Innovation Solution
A hemostatic material and wound dressing containing cationized cellulose, which has both hemostatic and antibacterial properties due to its positively charged functional group, providing a safer alternative for wound healing by suppressing bleeding and infection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If chitosan is used as a raw material for hemostatic material, then hemostatic effect and antibacterial effect are improved, but shellfish allergy risk and endotoxin contamination increase
Solution Approach 1:
The patent changes the chemical structure by replacing chitosan with cationized cellulose, which has similar positive charge properties for hemostasis but eliminates shellfish allergy risks. The cationization process modifies cellulose to achieve the desired hemostatic and antibacterial effects without the harmful associations of chitosan.
Solution Approach 2:
The patent uses cellulose, a natural and safe material, as a disposable hemostatic agent that can be easily discarded after use, avoiding the need for complex disposal procedures associated with chitosan-based materials that may cause allergic reactions.
2Reliability
If chitosan is used as a raw material for wound dressing, then antibacterial effect is improved, but endotoxin removal difficulty increases
Solution Approach 1:
The patent changes the base material from chitosan to cationized cellulose, which maintains the antibacterial effect through positive charge interactions with bacterial cell membranes while being easier to purify and free from endotoxin contamination risks.
Solution Approach 2:
The patent extracts and removes the problematic endotoxin contamination issue by selecting cellulose as the base material, which naturally resists endotoxin accumulation, thereby simplifying the manufacturing and purification processes.
3Ease of operation
If hydrogel is used as wound dressing component, then moist wound healing environment is provided, but antibacterial and hemostatic properties are lost
Solution Approach 1:
The patent creates a composite material combining cellulose with cationic groups that provide both the moist wound healing environment and the antibacterial/hemostatic properties. The cationized cellulose serves as a multifunctional material that integrates multiple benefits in a single component.
Solution Approach 2:
The patent makes the wound dressing material universal by designing cationized cellulose to perform multiple functions simultaneously: maintaining moisture, providing antibacterial protection, and achieving hemostasis, thereby eliminating the need for separate components for each function.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cationized cellulose wound dressing effectively promotes wound healing by stopping bleeding, reducing infection risk, and preventing bacterial growth, offering higher safety and efficacy compared to chitosan and hydrogel-based solutions.
Implementation Method 1
Chitosan has an amino group, and is positively charged depending on conditions to aggregate blood cells and to exhibit a hemostatic effect
Implementation Method 2
Chitosan has an amino group, and is positively charged depending on conditions to aggregate blood cells and to exhibit a hemostatic effect
Data Source
AI summary
A hemostatic material is described, which eliminates the risks of conventional chitosan-derived products, such as the onset of shellfish allergy and endotoxin contamination, can be used safely for more people, and has an antibacterial property and a hemostatic function that widely-used hydrogels lack, and a wound dressing containing the same. A hemostatic material containing cationized cellulose and a wound dressing containing the hemostatic are described. At least one of hydroxyl groups of the cationized cellulose is modified with —R2—N+(R3)(R4)(R5).X−, other hydroxyl groups of the cationized cellulose have —H, or —(CH2CH2O)m—H, R2 represents C1-6 alkylene, C2-6 hydroxyalkylene, —(CH2CH2O)1—, or a combination thereof, 1 represents 1 or 2, m represents 1 or 2, and X− may represent an anionic group.