CBD Capsule Bioavailability via Natural Ingredient Mediators
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Solution Overview
Problem
Current oral formulations of cannabinoids have low bioavailability due to high lipophilicity and poor dissolution in the gastrointestinal tract, limiting their therapeutic and supplement uses for conditions like menstrual and menopausal symptoms.
Innovation Solution
A combination of cannabidiol (CBD) with natural ingredients such as turmeric, ginger, and fennel, formulated in oral capsules for immediate or timed release, providing a synergistic effect for alleviating menstrual and menopausal symptoms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If oral formulations of cannabinoids are used, then convenience of administration is improved, but bioavailability is worsened due to high lipophilicity and poor dissolution in the gastrointestinal tract
Solution Approach 1:
The patent uses natural ingredients (turmeric, ginger, fennel, valerian root, cramp bark) as intermediary substances that facilitate the dissolution and absorption of CBD in the gastrointestinal tract. These ingredients act as carriers or enhancers that improve the bioavailability of the lipophilic CBD when taken orally, resolving the contradiction between convenience and bioavailability.
Solution Approach 2:
The patent creates a composite formulation combining CBD with multiple natural ingredients in a single oral capsule. This composite approach leverages the complementary properties of each ingredient to enhance overall efficacy and bioavailability while maintaining the convenience of oral administration. The synergistic combination addresses the limitations of pure CBD formulations.
2Device complexity
If CBD is used alone, then formulation simplicity is maintained, but therapeutic efficacy is insufficient for menstrual and menopausal symptoms
Solution Approach 1:
The patent merges CBD with multiple natural ingredients that have specific therapeutic properties relevant to menstrual and menopausal symptoms. This combination approach enhances therapeutic efficacy by addressing multiple symptom pathways simultaneously while maintaining a unified oral capsule formulation that remains relatively simple to administer.
Solution Approach 2:
The formulation is designed to address multiple symptoms and conditions (menstrual cramps, mood swings, hot flashes, inflammation) through the multi-functional action of the ingredient combination. Each ingredient contributes specific therapeutic effects, making the formulation universally applicable to various symptoms associated with menstrual and menopausal transitions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation enhances the bioavailability and efficacy of CBD, offering effective relief for symptoms like dysmenorrhea, irritability, and mood swings, with improved patient compliance through convenient oral administration.
Implementation Method 1
Cannabinoids are a class of diverse chemical compounds that act on cannabinoid receptors in cells and potentially alter neurotransmitter release in the brain. Both THC and CBD exert their effects by interacting with the G protein-coupled cannabinoid receptors (GPCRs), CB1 and CB2
Implementation Method 2
CB1 receptors are expressed in larger quantities in the brain and regions in the central nervous system... the CB2 receptors have been identified to be localized to immune cells, tonsils and the spleen
Implementation Method 3
inclusion of CBD with a number of different natural ingredients provides an unexpectedly superior formulation for the alleviation of pain and symptoms associated with the menstrual cycle or with the changes that occur during menopause. The use of the combination of ingredients appears to benefit the patient more than simply an additive effect, suggesting these chemicals act to provide a synergistic effect
Data Source
AI summary
The present application discloses natural compositions as medicaments and wellness products comprising of one or more cannabinoids and little or no THC comprised with other natural ingredients used for alleviating premenstrual, menstrual, and menopausal symptoms such as hot flashes, night sweats, mood changes, nausea, and Premenstrual Syndrome (PMS). The invention also contemplates methods of use of said compositions.