CBD Oil-in-Water Emulsion for Irritation-Free Pulmonary Delivery
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Solution Overview
Problem
The effective delivery of cannabidiol (CBD) via inhalation is challenging due to its highly lipophilic nature, leading to poor aqueous solubility and respiratory irritation when administered through smoking or vaporization, necessitating the development of compositions that can be safely and effectively delivered to pulmonary tissues.
Innovation Solution
A pharmaceutical composition comprising an oil-in-water emulsion with a dispersed oil phase containing CBD, formulated for inhalation using nebulization, which allows for the production of nanoscale oil droplets that can be delivered to pulmonary tissues, reducing respiratory irritation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If CBD is administered through smoking or vaporization, then respiratory irritation occurs, but CBD delivery to pulmonary tissues is achieved
Solution Approach 1:
The patent changes the physical and chemical parameters of CBD by formulating it as an oil-in-water emulsion with nanoscale droplet size (10-500 nm). This parameter change allows CBD to be delivered in an aerosol form suitable for inhalation without requiring combustion or high-temperature vaporization, thereby eliminating respiratory irritation while maintaining effective pulmonary delivery
Solution Approach 2:
The patent introduces an emulsion system as an intermediary carrier for CBD. The oil-in-water emulsion acts as a mediator that enables CBD to be aerosolized and delivered to pulmonary tissues without direct exposure to heat or combustion products, thus resolving the contradiction between effective delivery and respiratory irritation
2Object-affected harmful factors
If CBD is formulated for inhalation, then respiratory irritation is reduced, but poor aqueous solubility remains a challenge
Solution Approach 1:
The patent creates a composite emulsion system combining oil and water phases with CBD dissolved in the oil phase. This composite structure allows CBD to maintain its lipophilic properties in the oil phase while the external water phase and nanoscale droplet size enable aerosolization and pulmonary delivery without respiratory irritation
Solution Approach 2:
The patent segments CBD into nanoscale oil droplets (10-500 nm) dispersed in water. This segmentation increases the surface area to volume ratio and enables the lipophilic CBD to be delivered in an aqueous aerosol form, overcoming solubility limitations while maintaining low respiratory irritation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The emulsion formulation enables efficient delivery of CBD to pulmonary tissues, overcoming solubility issues and minimizing respiratory irritation, providing a potential treatment for traumatic brain injury (TBI) by reducing neuronal cell death during the secondary insult.
Implementation Method 1
a dispersed oil phase and a continuous water phase, wherein the dispersed oil phase comprises cannabidiol (CBD)
Implementation Method 2
A pharmaceutical composition comprising an oil-in-water emulsion with a dispersed oil phase containing CBD, formulated for inhalation using nebulization
Data Source
AI summary
The present invention relates to a pharmaceutical composition comprising an oil-in-water emulsion having a dispersed oil phase and a continuous water phase, wherein the dispersed oil phase comprises cannabidiol (CBD) or a pharmaceutically acceptable salt or functional derivative thereof, wherein the composition is formulated for administration by inhalation. The composition is intended for use in the treatment of traumatic brain injury (TBI).