Transdermal Patch With Hydrophilic Porous Membrane for CBD Delivery
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Solution Overview
Problem
Current transdermal devices for delivering cannabidiol (CBD) face limitations in mass transfer rate through the skin due to liquid carriers and adhesives, leading to suboptimal bioavailability and short duration of action, particularly affecting vulnerable populations like children and those with compromised immune systems.
Innovation Solution
A transdermal patch design featuring a porous hydrophilic membrane and a saturated alcohol solution or liquid matrix, with a microporous hydrophilic membrane and occlusive film, allowing for controlled and sustained delivery of CBD through the skin, circumventing the gastric system and liver first-pass metabolism.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If liquid carriers and hydrophobic rate-controlling membranes are used in reservoir-style transdermal devices, then the device can deliver CBD through the skin, but the rate of mass transfer of CBD through the skin is limited
Solution Approach 1:
The patent employs a hydrophilic porous membrane with controlled pore size and distribution to enhance the rate of mass transfer of CBD through the skin. The porous structure allows for improved permeability compared to hydrophobic membranes, enabling higher productivity in CBD delivery while maintaining controlled release characteristics.
Solution Approach 2:
The invention changes the fundamental parameter of membrane hydrophobicity to hydrophilicity, and adjusts the pore size parameters of the membrane to optimize CBD permeability. This parameter change resolves the contradiction by enabling both high mass transfer rate and reliable bioavailability through the hydrophilic porous membrane structure.
2Ease of operation
If adhesive is used to attach the transdermal device to the skin, then the device can be held in place, but the adhesive limits the rate of mass transfer of CBD to the skin
Solution Approach 1:
The patent extracts or removes the adhesive layer from the system by using a pressure-sensitive adhesive-free design where the hydrophilic porous membrane itself provides the interface with the skin. This elimination of adhesive removes the mass transfer limitation while maintaining device attachment through alternative mechanisms.
Solution Approach 2:
The hydrophilic porous membrane serves dual functions: providing structural support for device attachment to the skin and enabling high-rate mass transfer of CBD. The porous structure allows direct contact and permeability without the interfering layer of traditional adhesive.
3Ease of operation
If traditional creams and lotions are used for CBD delivery, then the medicine can be applied topically, but the product acts for a short time being rubbed off by cloth and washed off
Solution Approach 1:
The patent uses a flexible hydrophilic porous membrane as a thin film structure that provides sustained release of CBD. This membrane structure prevents the medicine from being easily rubbed off or washed off compared to traditional creams, while maintaining ease of topical application. The film structure enables duration of action extending up to 24-72 hours.
4Ease of operation
If oral CBD is taken, then the medicine can be administered conveniently, but the CBD is exposed to the gastric environment and liver metabolism which lowers bioavailability
Solution Approach 1:
The patent introduces the transdermal hydrophilic porous membrane as an intermediary delivery system that bypasses the gastric environment and liver first-pass metabolism. This intermediary route of delivery maintains the convenience of administration while dramatically improving bioavailability by delivering CBD directly through the skin into the bloodstream.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch achieves a higher cumulative flux of CBD, providing a therapeutically effective and sustained delivery for up to 24-72 hours, enhancing bioavailability and patient compliance compared to oral forms, while minimizing side effects.
Implementation Method 1
the porous hydrophilic membrane has a first side, and wherein the device has a release liner on the first side of the porous hydrophilic membrane
Implementation Method 2
delivering cannabidiol through the skin, circumventing the gastric system and liver first-pass metabolism
Implementation Method 3
A transdermal patch design featuring a porous hydrophilic membrane and a saturated alcohol solution or liquid matrix
Implementation Method 4
allowing for controlled and sustained delivery of CBD through the skin
Data Source
AI summary
Transdermal delivery devices for the delivery of cannabidiol (CBD) and related moieties are shown and described. In a reservoir-patch design, a microporous, hydrophilic membrane and a backing define a reservoir that houses a mixture of CBD, a polar liquid, and a gelling agent, along with other moieties that seem to be enhanced or bioavailability of increased by the same. The hydrophilic membrane is coated with an amine-compatible silicone skin adhesive. In a monolithic design, a release liner is coated with a mixture of CBD and a PIB or amine-compatible silicone skin adhesive laminated to the backing material. In using CBD as a pure compound or as one to combine with other moieties, the invention is able to control delivery better than the prior art. Construction of the transdermal patch of reservoir type is also taught, which enables things such as Vitamin B12 to become part of the complex deliverable by the inventions.