Amorphous CBDA Aerosol Composition for Stable CBD Delivery
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing aerosol generation systems for delivering cannabidiol (CBD) face challenges in stability and efficiency, particularly in non-combustible smoking articles and e-cigarette/tobacco hybrid devices, where CBD can oxidize during manufacture and storage, and the delivery mechanism is not optimal.
Innovation Solution
An amorphous solid composition comprising cannabidiolic acid (CBDA), aerosol-former material, gelling agent, and optionally filler, which is formulated into an aerosol-generating material for use in non-combustible aerosol provision systems, where CBDA is decarboxylated to form CBD upon heating, ensuring stability and effective delivery.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If CBD is used directly in aerosol generation systems, then delivery of CBD is achieved, but CBD oxidizes during manufacture and storage reducing stability
Solution Approach 1:
The patent applies preliminary action by using CBDA (cannabidiolic acid) instead of CBD in the initial formulation. CBDA is chemically more stable during manufacture and storage, preventing oxidation. The conversion from CBDA to CBD occurs in advance of actual use, through decarboxylation during the aerosol generation process, thus maintaining stability throughout the product lifecycle while ensuring CBD delivery when needed.
Solution Approach 2:
The patent employs parameter changes by transforming the chemical state of the cannabinoid from CBDA to CBD through thermal decarboxylation. This parameter change (chemical transformation) occurs during heating in the aerosol generation device, converting the stable storage form (CBDA) into the active delivery form (CBD), thus resolving the contradiction between storage stability and active ingredient delivery.
2Productivity
If heating is applied to convert CBDA to CBD, then CBD delivery is enhanced, but excessive heat may degrade other components
Solution Approach 1:
The patent utilizes phase transitions and thermal transformations by controlling the heating process to achieve decarboxylation of CBDA to CBD. The heating is sufficient to trigger the chemical transformation and volatilization needed for aerosol generation, but the amorphous solid matrix and formulation are designed to protect other components from degradation, thus enhancing CBD delivery while minimizing harmful effects.
Solution Approach 2:
The patent uses composite materials by formulating an amorphous solid containing CBDA, aerosol-former material, and gelling agent. This composite structure provides thermal protection to sensitive components during the heating process, allowing CBDA to convert to CBD and volatilize while the matrix protects other ingredients from degradation, thus resolving the contradiction between productivity and component stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The amorphous solid composition provides a stable and efficient delivery of CBD by maintaining CBDA stability during storage and converting it to CBD upon heating, enhancing the delivery of high CBD levels in inhalable aerosols.
Implementation Method 1
CBDA is decarboxylated to form CBD upon heating
Implementation Method 2
The heating volatilises at least one component of the material, typically forming an inhalable aerosol
Data Source
Figure 1~2
Figure 3~4
Figure 5
AI summary
The present invention provides an amorphous solid for use in aerosol generation, the amorphous solid comprising: about 1 to about 50 wt% cannabidiolic acid (CBDA); about 10 to about 80 wt% aerosol-former material; gelling agent; and optionally filler, wherein the amount of gelling agent and optional filler taken together is from about 10 to about 60 wt%; wherein the wt% values are calculated on a dry weight basis.