CBDv Isolation via Multi-Step Alkane Crystallization
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Solution Overview
Problem
Current methods for isolating cannabidivarin (CBDv) from hemp plants are costly, complex, and inefficient, particularly when extracting it from full spectrum distillates.
Innovation Solution
A multi-step crystallization process involving dissolving distillates in alkane solvent and cooling to form crystals, with repeated crystallization steps to achieve CBDv concentrations greater than 97 wt%, along with optional purification steps to enhance CBDv content.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional isolation techniques are used to isolate CBDv from full spectrum distillates, then CBDv can be obtained, but the process becomes costly, complex, and inefficient
Solution Approach 1:
The patent applies parameter changes by systematically varying temperature, solvent ratios, and crystallization conditions across multiple sequential crystallization steps. Each step uses optimized parameters to progressively increase CBDv purity from the distillate to final isolate form, achieving high purity without complex equipment
Solution Approach 2:
The isolation process is segmented into multiple discrete crystallization steps, where each step performs a specific purification function. The first crystallization removes initial impurities, the second crystallization further purifies, and subsequent steps achieve final high purity levels. This segmentation allows each step to be optimized independently while maintaining overall process simplicity
2Manufacturing precision
If conventional isolation techniques are used to isolate CBDv from full spectrum distillates, then CBDv can be obtained, but the process becomes costly and inefficient
Solution Approach 1:
The patent implements continuous useful action by using the output of each crystallization step directly as the input for the next step without intermediate purification or processing. The mother liquor from one crystallization becomes the feed for the next, and crystals are directly redissolved in optimized solvent ratios. This continuous flow approach eliminates downtime and maximizes productivity while maintaining high purity
Solution Approach 2:
Each crystallization step uses differently optimized parameters including temperature ranges, solvent-to-substrate ratios, and cooling rates. These parameter changes are specifically tuned to maximize both purity gain and processing speed at each stage, with earlier steps optimized for bulk purification and later steps for fine purification, thereby improving overall productivity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method effectively increases CBDv purity to high concentrations, making the isolation process more efficient and cost-effective by repeatedly dissolving and cooling crystals in alkane solvent, resulting in CBDv isolates with desired purity levels.
Implementation Method 1
dissolving a distillate comprising CBDv, such as a full spectrum distillate obtained from hemp extract, in alkane solvent to form a first solution
Implementation Method 2
cooling the first solution to form first crystals having a CBDv content
Implementation Method 3
cooling the first solution to form first crystals
Data Source
AI summary
A method of preparing a cannabidivarin (CBDv) isolate generally includes a step of dissolving a distillate comprising (cannabidivarin), such as a full spectrum distillate obtained from hemp extract, in alkane solvent to form a first solution, cooling the first solution to within a first temperature range to thereby form first crystals comprising CBDv, dissolving the first crystals in alkane solvent to form a second solution, cooling the second solution to within a second temperature range to thereby form second crystals having a higher CBDv content than the first crystals, dissolving the second crystals in alkane solvent to form a third solution, and cooling the third solution to within a third temperature range to thereby form third crystals having a higher CBDv content than the second crystals. The method can be carried out to prepare crystals having a CBDv content greater than 97 wt %, such as greater than 99 wt % or greater than 99.9 wt %.