CCD Detector Gate Voltage Adjustment for Biological Analysis
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Solution Overview
Problem
Conventional charge-coupled device (CCD) systems in biological analysis have fixed operating parameters, limiting their flexibility and effectiveness in detecting signals from samples, as they do not adapt to varying analysis situations.
Innovation Solution
A system with a segmented detector and a controller that adjusts gate voltage amplitude and duration, as well as readout parameters, such as reset time and electron multiplier gain, to enhance charge transfer and readout processes, allowing for improved detection and identification of particles in biological samples.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If CCD operating parameters are set to fixed configurations when the system is received, then the system is simple to operate and maintain, but the system lacks flexibility to adapt to varying analysis situations
Solution Approach 1:
The patent implements dynamic adjustability of CCD operating parameters including gate voltage amplitude, gate voltage duration, and readout parameters. The controller enables real-time modification of these parameters during operation, transforming the fixed configuration into a dynamic system that can adapt to different analysis situations while maintaining operational simplicity through automated control.
Solution Approach 2:
The system allows changing of critical operating parameters such as gate voltage amplitude, gate voltage duration, reset time, and electron multiplier gain. These parameter changes enable the CCD to optimize its performance for different biological analysis applications without requiring physical reconfiguration or complex system changes.
2Measurement precision
If conventional fixed-parameter CCD systems are used, then the device complexity is low, but the measurement precision and detection effectiveness are limited
Solution Approach 1:
By enabling dynamic adjustment of gate voltage amplitude and duration along with readout parameters like reset time and electron multiplier gain, the system optimizes charge transfer and readout processes for different signal conditions, thereby improving measurement precision without requiring a complete system redesign.
3Reliability
If the gate voltage amplitude and duration are adjusted to optimize charge transfer, then the detection performance is improved, but the control system complexity increases
Solution Approach 1:
The controller monitors the detection process and automatically adjusts gate voltage amplitude and duration to optimize charge transfer efficiency. This feedback mechanism ensures reliable charge transfer while minimizing the need for manual intervention and complex user-side control configurations.
Solution Approach 2:
The system performs self-optimization of charge transfer parameters through automated control, where the controller independently adjusts gate voltage settings based on detection requirements, eliminating the need for complex external control systems or manual tuning by the user.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This configuration enhances the flexibility and performance of CCD systems in biological analysis by optimizing charge transfer and readout processes, leading to better identification of particles and improved analysis outcomes.
Implementation Method 1
The signal detection for a given pixel can be characterized as a conversion of an incident electromagnetic energy signal into a number of electron-hole pairs
Data Source
AI summary
A system and method for allowing adjustments of various parameters associated with the operation of charge-coupled devices adapted for use in biological analysis devices. Gate voltage signal applied to the CCDs can be adjusted to advantageously affect the manner in which charge is transferred from pixels. The manner in which transferred charges from the pixels are processed in a readout process can also be adjusted to advantageously change the speed of the CCD based detector. Various methods of performing such adjustments are disclosed.