Cyclodextrin-Based Metal Organic Framework Sustained Release
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Solution Overview
Problem
Existing compositions fail to maintain a sustained release of active agents over an extended period, leading to inefficient delivery and reduced therapeutic or cosmetic effects.
Innovation Solution
Incorporating a cyclodextrin-based metal organic framework (CD-MOF) into compositions containing active agents, which acts as a reservoir to steadily release the agents, enhancing the release profile by increasing the average release rate and duration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional compositions are used to deliver active agents, then the composition is simple and easy to manufacture, but the release duration and sustained delivery are insufficient
Solution Approach 1:
The patent employs composite materials by combining cyclodextrin molecules with metal cations to form a metal organic framework (MOF) structure. This composite material integrates the host-guest capability of cyclodextrins with the structural stability of MOFs, creating a system that provides both sustained release functionality and structural integrity. The composite structure enables prolonged active agent delivery while maintaining compositional feasibility through established synthesis methods.
Solution Approach 2:
The cyclodextrin-based metal organic framework utilizes porous material characteristics to provide a three-dimensional framework with channels and cavities that can accommodate and slowly release active agents. The porous structure of the MOF allows for controlled diffusion and sustained delivery of the active agent over extended periods, directly addressing the release duration requirement while the framework itself serves as the delivery system rather than requiring additional complex components.
2Quantity of substance
If conventional compositions are used, then the manufacturing process is simple, but the total release amount of active agent is limited
Solution Approach 1:
The patent applies the nesting principle by placing active agents within the hierarchical structure of the cyclodextrin-based MOF. The active agents are nested within the porous framework and cyclodextrin cavities, allowing for high loading capacities. This nested arrangement maximizes the total release amount by utilizing multiple levels of containment (MOF framework, cyclodextrin units, and guest molecules) without requiring complex multi-step manufacturing processes, as the nesting occurs during the formation of the MOF structure itself.
3Duration of action of stationary object
If conventional compositions are used, then the composition formulation is straightforward, but the release profile is not sustained over extended periods
Solution Approach 1:
The cyclodextrin-based MOF employs self-service mechanisms where the porous framework and cyclodextrin units automatically and continuously release active agents through diffusion and desorption processes without requiring external intervention. The structure itself provides the sustained release functionality through its inherent properties, eliminating the need for complex control systems, pumps, or external power sources. The release is driven by the natural thermodynamic processes of the material system, maintaining sustained release over extended periods while keeping the mechanism relatively simple.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The CD-MOF significantly improves the release profile by maintaining the active agent's release for a longer period and increasing the total release amount, providing a more effective and prolonged cosmetic or therapeutic effect compared to compositions without CD-MOF.
Implementation Method 1
The CD-MOF includes at least a metal cation and a plurality of cyclodextrin molecules... acts as a reservoir to steadily release the agents
Implementation Method 2
This structure gives CDs the ability to host guest molecules (complexant) within their cavity. Due to this ability to form inclusion compounds (complex) with a wide variety of chemicals
Data Source
AI summary
This disclosure relates to a composition that includes an active agent and a porous cyclodextrin-based metal organic framework (CD-MOF). The CD-MOF includes at least a metal cation and a plurality of cyclodextrin molecules. The composition includes from about 0.05 mg to about 0.5 mg of the active agent per 1 mg of the CD-MOF. Methods of preparing and using the compositions are also disclosed.